LEADER 04520nam 22005775 450 001 9910298598803321 005 20200629185248.0 010 $a3-319-65587-6 024 7 $a10.1007/978-3-319-65587-1 035 $a(CKB)4340000000223343 035 $a(DE-He213)978-3-319-65587-1 035 $a(MiAaPQ)EBC5152986 035 $a(PPN)221254692 035 $a(EXLCZ)994340000000223343 100 $a20171120d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCoupling and Decoupling of Diverse Molecular Units in Glycosciences /$fedited by Zbigniew J. Witczak, Roman Bielski 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (XIV, 335 p. 244 illus., 81 illus. in color.) 311 $a3-319-65586-8 320 $aIncludes bibliographical references. 327 $aSynthesis of N-linked glycopeptides using convergent enzymatic glycosylation combined with SPPS.- Synthetic Antitumor Vaccines through Coupling of Mucin Glycopeptide Antigens to Proteins.- Recent Advances in the Stereochemical Outcome of Multi Component Reactions Involving Convertible Isocyanides.- Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE.- Selective Transformations of the Anomeric Centre in Water Using DMC and Derivatives -- [3,3]-Sigmatropic Rearrangement as a Powerful Synthetic Tool on Skeletal Modification of Unsaturated Sugars --  Recognition of thiols in coupling reactions to organic and carbohydrate acceptors.- Chemical approaches toward neurodegenerative disease prevention: the role of coupling sugars to phenolic biomolecular entities --  Probing for Trypanosoma cruzi cell surface glycobiomarkers for the diagnosis and follow-up of chemotherapy of Chagas disease --  Syntheses and Functions Glycosaminoglycan Mimicking Polymers.- Methods for the high resolution analysis of glycoconjugates.- Masking Strategies for the Bioorthogonal Release of Anticancer Glycosides.- Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry.- Increased efficacy of NKT cell adjuvanted peptide vaccines through chemical conjugation. 330 $aThis unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book. 606 $aMedicinal chemistry 606 $aCarbohydrates 606 $aBioorganic chemistry 606 $aBiomaterials 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aCarbohydrate Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19030 606 $aBioorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19010 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 615 0$aMedicinal chemistry. 615 0$aCarbohydrates. 615 0$aBioorganic chemistry. 615 0$aBiomaterials. 615 14$aMedicinal Chemistry. 615 24$aCarbohydrate Chemistry. 615 24$aBioorganic Chemistry. 615 24$aBiomaterials. 676 $a615.19 702 $aWitczak$b Zbigniew J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBielski$b Roman$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298598803321 996 $aCoupling and Decoupling of Diverse Molecular Units in Glycosciences$91563759 997 $aUNINA