LEADER 03709nam 22005535 450 001 9910298598303321 005 20200702221807.0 010 $a3-319-68097-8 024 7 $a10.1007/978-3-319-68097-2 035 $a(CKB)3810000000358866 035 $a(MiAaPQ)EBC5448147 035 $a(DE-He213)978-3-319-68097-2 035 $a(PPN)229493831 035 $a(EXLCZ)993810000000358866 100 $a20180628d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntibacterials $eVolume I /$fedited by Jed F. Fisher, Shahriar Mobashery, Marvin J. Miller 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (203 pages) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v25 311 $a3-319-68096-X 327 $aAntibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success -- The Antibiotic Future -- Synergistic Antibiotic Combinations -- Antibiotic Adjuvants -- Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes -- Four Ways to Skin a Cat: Inhibition of Bacterial Topoisomerases Leading to the Clinic -- The Clinical Development of Antibacterial Drugs: A Guide for the Discovery Scientist. 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v25 606 $aMedicinal chemistry 606 $aBiochemistry 606 $aOrganic chemistry 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 615 0$aMedicinal chemistry. 615 0$aBiochemistry. 615 0$aOrganic chemistry. 615 14$aMedicinal Chemistry. 615 24$aBiochemistry, general. 615 24$aOrganic Chemistry. 676 $a616.92061 702 $aFisher$b Jed F$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMobashery$b Shahriar$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMiller$b Marvin J$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298598303321 996 $aAntibacterials$91566645 997 $aUNINA