LEADER 04239nam  22005775  450 
001 9910298586403321
005 20200704132639.0
010   $a978-981-13-0773-7
010   $a981-13-0773-3
024 7 $a10.1007/978-981-13-0773-7
035   $a(CKB)4100000004974482
035   $a(MiAaPQ)EBC5437375
035   $a(DE-He213)978-981-13-0773-7
035   $a(PPN)22949286X
035   $a(EXLCZ)994100000004974482
100   $a20180626d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aTargeting Protein-Protein Interactions by Small Molecules /$fedited by Chunquan Sheng, Gunda I. Georg
205   $a1st ed. 2018.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018.
215   $a1 online resource (332 pages)
311   $a981-13-0772-5 
327   $aPart 1 Current strategies for the discovery of small-molecule inhibitors of protein?protein interactions -- Overview of Protein-protein Interactions and Small Molecule Inhibitors under Clinical Development -- High throughput screening in the discovery of small molecule inhibitors of protein-protein interactions -- Hot Spot-Based Design of Small-Molecule Inhibitors for Protein?Protein Interactions -- Computational Methods Applicable to the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions -- Experimental Methods Used for Identifying Small-Molecule Inhibitors of Protein-protein Interaction -- Fragment-based Drug Discovery for Developing Inhibitors of Protein-protein Interactions -- Part 2 Case studies of small-molecule inhibitors of protein?protein interactions -- Small molecule inhibitors targeting new targets of protein-protein interactions -- The Development of New Spirooxindoles Targeting the p53-MDM2 Protein-Protein Interactions for Cancer Therapy -- Small-Molecule Inhibitors for the ?-Catenin/T-Cell Factor Protein?Protein Interaction -- Discovery and development of Keap1-Nrf2 protein-protein interaction inhibitors -- BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status -- Targeting Protein-Protein Interactions in Small GTPases.
330   $aThis book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities. .
606   $aMedicinal chemistry
606   $aPharmaceutical technology
606   $aBioorganic chemistry
606   $aProteins 
606   $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000
606   $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010
606   $aBioorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19010
606   $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040
615  0$aMedicinal chemistry.
615  0$aPharmaceutical technology.
615  0$aBioorganic chemistry.
615  0$aProteins .
615 14$aMedicinal Chemistry.
615 24$aPharmaceutical Sciences/Technology.
615 24$aBioorganic Chemistry.
615 24$aProtein Science.
676   $a572.64
702   $aSheng$b Chunquan$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGeorg$b Gunda I$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298586403321
996   $aTargeting Protein-Protein Interactions by Small Molecules$91566668
997   $aUNINA