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010   $a3-319-77706-8
024 7 $a10.1007/978-3-319-77706-1
035   $a(CKB)4100000004243814
035   $a(DE-He213)978-3-319-77706-1
035   $a(MiAaPQ)EBC5404503
035   $a(PPN)227399323
035   $a(EXLCZ)994100000004243814
100   $a20180528d2018      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCarbohydrate-Based Interactions at the Molecular and the Cellular Level /$fby Kieran L. Hudson
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (XXIX, 198 p. 98 illus., 49 illus. in color.) 
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
311   $a3-319-77705-X 
327   $aIntroduction -- Protein-Carbohydrate Interactions in Protein X-ray Crystal Structures -- The Nature of Protein-Carbohydrate Interactions -- The Modifiable Scaffold for Tissue Engineering -- Carbohydrate Modifiers for Tissue Engineering Scaffolds -- Conclusions and Future Directions -- Experimental Details and Supplementary Data.
330   $aThis book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH?pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aCarbohydrates
606   $aProteins 
606   $aChemistry, Physical and theoretical
606   $aRegenerative medicine
606   $aTissue engineering
606   $aPhysical chemistry
606   $aAnalytical chemistry
606   $aCarbohydrate Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19030
606   $aProtein-Ligand Interactions$3https://scigraph.springernature.com/ontologies/product-market-codes/L14060
606   $aTheoretical and Computational Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C25007
606   $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080
606   $aPhysical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C21001
606   $aAnalytical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C11006
615  0$aCarbohydrates.
615  0$aProteins .
615  0$aChemistry, Physical and theoretical.
615  0$aRegenerative medicine.
615  0$aTissue engineering.
615  0$aPhysical chemistry.
615  0$aAnalytical chemistry.
615 14$aCarbohydrate Chemistry.
615 24$aProtein-Ligand Interactions.
615 24$aTheoretical and Computational Chemistry.
615 24$aRegenerative Medicine/Tissue Engineering.
615 24$aPhysical Chemistry.
615 24$aAnalytical Chemistry.
676   $a547.78
700   $aHudson$b Kieran L$4aut$4http://id.loc.gov/vocabulary/relators/aut$0768763
906   $aBOOK
912   $a9910298585703321
996   $aCarbohydrate-Based Interactions at the Molecular and the Cellular Level$91566608
997   $aUNINA