LEADER 03852nam 22006735 450 001 9910298584603321 005 20200705172916.0 010 $a3-030-00853-3 024 7 $a10.1007/978-3-030-00853-6 035 $a(CKB)4100000006999362 035 $a(MiAaPQ)EBC5534440 035 $a(DE-He213)978-3-030-00853-6 035 $a(PPN)231462220 035 $a(EXLCZ)994100000006999362 100 $a20181001d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins$b[electronic resource] /$fby Raphael Enoque Ferraz de Paiva 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (184 pages) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-030-00852-5 327 $aAu(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy. 330 $aThis book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C?S coupling. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aInorganic chemistry 606 $aOrganometallic chemistry  606 $aProteins  606 $aMass spectrometry 606 $aBioorganic chemistry 606 $aImmunology 606 $aInorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C16008 606 $aOrganometallic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19020 606 $aProtein-Ligand Interactions$3https://scigraph.springernature.com/ontologies/product-market-codes/L14060 606 $aMass Spectrometry$3https://scigraph.springernature.com/ontologies/product-market-codes/C11010 606 $aBioorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19010 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aInorganic chemistry. 615 0$aOrganometallic chemistry . 615 0$aProteins . 615 0$aMass spectrometry. 615 0$aBioorganic chemistry. 615 0$aImmunology. 615 14$aInorganic Chemistry. 615 24$aOrganometallic Chemistry. 615 24$aProtein-Ligand Interactions. 615 24$aMass Spectrometry. 615 24$aBioorganic Chemistry. 615 24$aImmunology. 676 $a571.845 700 $aFerraz de Paiva$b Raphael Enoque$4aut$4http://id.loc.gov/vocabulary/relators/aut$01059031 906 $aBOOK 912 $a9910298584603321 996 $aGold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins$92503745 997 $aUNINA