LEADER 04412nam 22010333a 450 001 9910367564003321 005 20250203235427.0 010 $a9783039214648 010 $a3039214640 024 8 $a10.3390/books978-3-03921-464-8 035 $a(CKB)4100000010106106 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42637 035 $a(ScCtBLL)dde03a7c-32d5-4378-9cf8-13aef749f272 035 $a(OCoLC)1163813930 035 $a(oapen)doab42637 035 $a(EXLCZ)994100000010106106 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCancer Biomarkers and Targets in Digestive Organs$fNelson Yee, Nikki Lee 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (146 p.) 311 08$a9783039214631 311 08$a3039214632 330 $aIdentification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases. 606 $aMedicine$2bicssc 610 $aliver graft injury 610 $aHFE 610 $aneurokinin 610 $achemotherapy 610 $aintestinal tumors 610 $atherapeutic targets 610 $abiliary tract carcinoma 610 $ahepatocellular carcinoma 610 $aclinical trial 610 $acell adhesion molecules 610 $acolorectal cancer 610 $abiomarkers 610 $aphenotypic mosaics 610 $agastrointestinal oncology 610 $aAsian Cancer Research Group (ACRG) 610 $abiomarker 610 $apsychosocial support 610 $aprecision therapy 610 $apancreatic carcinoma 610 $aprecision medicine 610 $aLiver transplantation 610 $apredictive biomarkers 610 $aCD274 610 $acholecystokinin 610 $aThe Cancer Genome Atlas (TCGA) 610 $agastrin 610 $apembrolizumab 610 $aimmunotherapy 610 $agastrin-releasing peptide 610 $astereotactic body radiation therapy 610 $aimmunohistochemistry 610 $agastric carcinoma 610 $aliver transplant 610 $aCAM invasion assay 610 $aintragraft gene expression profiles 610 $amolecular profiling 610 $atargeted therapy 610 $aneurotensin 610 $aintestinal disorder 610 $aramucirumab 610 $anext-generation sequencing 610 $acolorectal carcinoma 610 $atumor progenitor 610 $acirculating tumor cells 610 $agastrointestinal malignancies 610 $abombesin 610 $atrastuzumab 610 $asomatostatin 610 $azebrafish 610 $aG protein-coupled receptors 615 7$aMedicine 700 $aYee$b Nelson$01786932 702 $aLee$b Nikki 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910367564003321 996 $aCancer Biomarkers and Targets in Digestive Organs$94319463 997 $aUNINA LEADER 03569nam 22006255 450 001 9910298549403321 005 20250930154306.0 010 $a3-319-01399-8 024 7 $a10.1007/978-3-319-01399-2 035 $a(CKB)2670000000428543 035 $a(EBL)1466794 035 $a(SSID)ssj0001004934 035 $a(PQKBManifestationID)11564842 035 $a(PQKBTitleCode)TC0001004934 035 $a(PQKBWorkID)11050840 035 $a(PQKB)10237555 035 $a(MiAaPQ)EBC1466794 035 $a(DE-He213)978-3-319-01399-2 035 $a(PPN)172423872 035 $a(EXLCZ)992670000000428543 100 $a20130911d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAssembly Line Planning and Control /$fby Nick T. Thomopoulos 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (152 p.) 300 $aDescription based upon print version of record. 311 08$a3-319-01398-X 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Assembly Systems -- Some Fundamentals -- Preliminary Planning -- Inventory Replenishments -- Single Model Assembly -- Mixed Model Make-to-Stock Assembly -- Mixed Model Make-to-Order Assembly -- Postponement Assembly -- One Station Assembly -- Similarity Index -- Learning Curves. 330 $aAssembly Line Planning and Control describes the basic fundamentals of assembly lines for single model lines, mixed model make-to-stock lines, mixed model make-to-order lines and for one-station assembly. The book shows how to select the quantity of units to schedule for a shift duration, compute the number of operators needed on a line, set the conveyor speed, coordinate the main line with sub-assembly lines, assign the work elements to the operators on the line, sequence the models down the line, sequence the jobs down the line, calculate the part and component requirements for a line and for each station, determine the replenish needs of the parts and components from the suppliers, compute the similarity between the models being produced and show applications, use learning curves to estimate time and costs of assembly, and measure the efficiency of the line. The material is timeless and the book will never become obsolete. The author presents solutions with easy-to-understand numerical examples that can be applied to real-life applications. 606 $aOperations research 606 $aDecision making 606 $aProduction management 606 $aManufactures 606 $aOperations Research/Decision Theory$3https://scigraph.springernature.com/ontologies/product-market-codes/521000 606 $aOperations Management$3https://scigraph.springernature.com/ontologies/product-market-codes/519000 606 $aManufacturing, Machines, Tools, Processes$3https://scigraph.springernature.com/ontologies/product-market-codes/T22050 615 0$aOperations research. 615 0$aDecision making. 615 0$aProduction management. 615 0$aManufactures. 615 14$aOperations Research/Decision Theory. 615 24$aOperations Management. 615 24$aManufacturing, Machines, Tools, Processes. 676 $a658.40301 700 $aThomopoulos$b Nicholas T.$4aut$4http://id.loc.gov/vocabulary/relators/aut$01863627 906 $aBOOK 912 $a9910298549403321 996 $aAssembly Line Planning and Control$94472640 997 $aUNINA