LEADER 02016nam 2200505Ia 450 001 9910777341003321 005 20230617030850.0 010 $a1-74076-058-1 035 $a(CKB)1000000000000371 035 $a(EBL)184022 035 $a(OCoLC)85845105 035 $a(SSID)ssj0000276640 035 $a(PQKBManifestationID)11206016 035 $a(PQKBTitleCode)TC0000276640 035 $a(PQKBWorkID)10226082 035 $a(PQKB)10769451 035 $a(MiAaPQ)EBC184022 035 $a(Au-PeEL)EBL184022 035 $a(CaPaEBR)ebr10057347 035 $a(EXLCZ)991000000000000371 100 $a20010201d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAcross the magic line$b[electronic resource] $egrowing up in Fiji /$fPatricia Page 210 $aSydney $cPandanus$dc2004 215 $a1 online resource (279 p.) 300 $aDescription based upon print version of record. 311 $a1-74076-048-4 327 $aAcknowledgements; Fijian Spelling; Contents; 1. Full Circle; 2. A Place in the Universe; 3. Cannibal Forks; 4. Sharks and Husbands; 5. Coming Soon: Big Mac; 6. A Touch of the Tar Brush; 7. War Games; 8. The Lady and the Cannibals; 9. White Water; 10. The Memory Necklace; 11. The Most Beautiful Island of All; 12. Coconuts and Castor Oil; 13. Honeymoon Island; 14. Mr Strong; 15. First Love; 16. Pets and Pedal Drills; 17. The Sailing Ship; 18. The Driftwood House; 19. Lonely Levuka; 20. Dead Selves; Notes; Bibliography; Map, Fiji Islands; 330 $aA memoir of an expatriate childhood in Fiji, recollected on a visit 50 years later. 606 $aWorld War, 1939-1945$zFiji 607 $aFiji$xHistory 615 0$aWorld War, 1939-1945 676 $a996.11 700 $aPage$b Patricia$01485533 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910777341003321 996 $aAcross the magic line$93704727 997 $aUNINA LEADER 03837nam 2200445z- 450 001 9910136793803321 005 20210212 035 $a(CKB)3710000000631050 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/60979 035 $a(oapen)doab60979 035 $a(EXLCZ)993710000000631050 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aToll-Like Receptor Activation in Immunity vs. Tolerance 210 $cFrontiers Media SA$d2015 215 $a1 online resource (75 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-636-4 330 $aThe innate immune system has evolved means to recognize and react suitably to foreign entities such as infectious agents. In many cases infectious microorganisms threaten the integrity and function of the target organs or tissues; therefore, consequent to their recognition the immune system becomes activated to ensure their elimination. Toll-like receptors (TLR) constitute a family of receptors specialized in the recognition of molecular patterns typically associated with infectious agents. Different TLRs exist, each selective for molecular entities and motifs belonging to a specific pathogen group. Consequently, it is thought that the molecular nature of invading microorganisms activates specific TLRs to drive adequate anti-infectious immunity. For instance, nucleic acid-specific, intracellular receptors (TLR3/7/8/9) are used to sense viruses and drive antiviral immunity, while other receptors (such as TLR2 and TLR4) recognize and promote immunity against bacteria, yeast, and fungi. Yet, it is becoming evident that activation of TLR pathways trigger mechanisms that not only stimulate but also regulate the immune system. For instance, TLR stimulation by viruses will drive antiviral interferon but also immunoregulatory cytokine production and regulatory T cell activation. Stimulation of TLRs by bacteria or using molecular agonists can also trigger both immune stimulatory and regulatory responses. TLR stimulation by infectious agents likely serves to activate but also control anti-infectious immunity, for instance prevent potential immunopathological tissue damage which can be caused by acute immune defense mechanisms. Previous work by us and others has shown that the immunoregulatory arm of TLR stimulation can additionally help control autoreactive processes in autoimmune disease. Hence, it is becoming established that gut commensals, which also play a crucial part in the control of autoimmune disease, establish immune regulatory mechanisms through activation of particular TLRs. In sum, it appears that TLRs are key immune players that not only stimulate but also regulate immune processes in health and disease. In this Research Topic, we wish to review the dual role of TLRs as activators and regulators of immune responses. We aim to motivate data-driven opinions as to the importance of context of TLR agonism for determining immune activation vs. regulation. The presentation of ongoing original works, as well as data and opinions around other innate immune receptors pertaining to this topic, are also encouraged. 606 $aMedicine$2bicssc 610 $aAutoimmune Diseases 610 $acancer immunotherapy 610 $aImmune stimulation 610 $aImmunoregulation 610 $aInfection 610 $aInflammation 610 $amicrobiome 610 $aProbiotics 610 $atolerance 610 $aToll-Like Receptors 615 7$aMedicine 700 $aChristophe M. Filippi$4auth$01297628 906 $aBOOK 912 $a9910136793803321 996 $aToll-Like Receptor Activation in Immunity vs. Tolerance$93024636 997 $aUNINA LEADER 03645nam 22007095 450 001 9910298462003321 005 20251117074853.0 010 $a1-4471-6428-8 024 7 $a10.1007/978-1-4471-6428-9 035 $a(CKB)3710000000117696 035 $a(EBL)1719946 035 $a(OCoLC)882769602 035 $a(SSID)ssj0001237437 035 $a(PQKBManifestationID)11818035 035 $a(PQKBTitleCode)TC0001237437 035 $a(PQKBWorkID)11249244 035 $a(PQKB)10757915 035 $a(MiAaPQ)EBC1719946 035 $a(DE-He213)978-1-4471-6428-9 035 $a(PPN)178779903 035 $a(EXLCZ)993710000000117696 100 $a20140521d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Handbook of Graphene Electrochemistry /$fby Dale A. C. Brownson, Craig E. Banks 205 $a1st ed. 2014. 210 1$aLondon :$cSpringer London :$cImprint: Springer,$d2014. 215 $a1 online resource (208 p.) 300 $aDescription based upon print version of record. 311 08$a1-4471-6427-X 320 $aIncludes bibliographical references at the end of each chapters. 327 $a1 Introduction to graphene -- 2 Interpreting electrochemistry -- 3 The electrochemistry of graphene -- 4 Graphene applications. 330 $aGraphene has grasped the attention of academia and industry world-wide due its unique structure and reported advantageous properties. This was reflected via the 2010 Nobel Prize in Physics being awarded for groundbreaking experiments regarding the two-dimensional material graphene. One particular area in which graphene has been extensively explored is electrochemistry where it is potentially the world?s thinnest electrode material. Graphene has been widely reported to perform beneficially over existing electrode materials when used within energy production or storage devices and when utilised to fabricate electrochemical sensors. This book charts the history of graphene, depicting how it has made an impact in the field of electrochemistry and how scientists are trying to unravel its unique properties, which has, surprisingly led to its fall from grace in some areas. A fundamental introduction into Graphene Electrochemistry is given, through which readers can acquire the tools required to effectively explain and interpret the vast array of graphene literature. The readers is provided with the appropriate insights required to be able to design and implement diligent electrochemical experiments when utilising graphene as an electrode material. 606 $aElectrochemistry 606 $aOptical materials 606 $aEnergy storage 606 $aElectronics 606 $aElectrochemistry 606 $aOptical Materials 606 $aMechanical and Thermal Energy Storage 606 $aElectronics and Microelectronics, Instrumentation 615 0$aElectrochemistry. 615 0$aOptical materials. 615 0$aEnergy storage. 615 0$aElectronics. 615 14$aElectrochemistry. 615 24$aOptical Materials. 615 24$aMechanical and Thermal Energy Storage. 615 24$aElectronics and Microelectronics, Instrumentation. 676 $a54 676 $a540.151 676 $a541.37 676 $a620.11295 700 $aBrownson$b Dale A. C.$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058812 702 $aBanks$b Craig E.$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298462003321 996 $aThe Handbook of Graphene Electrochemistry$92502639 997 $aUNINA