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100   $a20150930d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aAdmixture Dynamics, Natural Selection and Diseases in Admixed Populations /$fby Wenfei Jin
205   $a1st ed. 2015.
210  1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015.
215   $a1 online resource (126 p.)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $aDescription based upon print version of record.
311   $a94-017-7406-4 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aIntroduction -- Distribution of length of ancestral chromosomal segments in admixed genomes -- Exploring population admixture dynamics via distribution of LACS -- Genome-wide search for signatures of natural selection in African Americans -- Complex selective forces shaping the genes underlying human diseases -- Materials and Methods.
330   $aIn this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aHuman genetics
606   $aBioinformatics
606   $aBiomathematics
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001
606   $aGenetics and Population Dynamics$3https://scigraph.springernature.com/ontologies/product-market-codes/M31010
615  0$aHuman genetics.
615  0$aBioinformatics.
615  0$aBiomathematics.
615 14$aHuman Genetics.
615 24$aBioinformatics.
615 24$aGenetics and Population Dynamics.
676   $a578.4
700   $aJin$b Wenfei$4aut$4http://id.loc.gov/vocabulary/relators/aut$01065334
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910298460503321
996   $aAdmixture Dynamics, Natural Selection and Diseases in Admixed Populations$92544749
997   $aUNINA