LEADER 00854nam0-22003011i-450- 001 990003270550403321 005 20001010 035 $a000327055 035 $aFED01000327055 035 $a(Aleph)000327055FED01 035 $a000327055 100 $a20000920d1933----km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $a<>AMBIENTE GEOGRAFICO E LO SVILUPPO ECONOMICO NEL GORIZIANO 210 $aGorizia$cTipografia Giuseppe Lucchi$d1933 215 $app. 231 610 0 $aFriuli V. G. 676 $a074.008 700 1$aMassi,$bErnesto$f<1909-1997>$075857 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003270550403321 952 $a074.008.MAS$b12662$fDECGE 959 $aDECGE 996 $aAMBIENTE GEOGRAFICO E LO SVILUPPO ECONOMICO NEL GORIZIANO$9450758 997 $aUNINA DB $aING01 LEADER 02073nam 22006135u 450 001 9910157659003321 005 20211006145105.0 010 $a9783318035308 010 $a3318035300 035 $a(CKB)3780000000101696 035 $a(OCoLC)967540272 035 $a(SZ-BaSKA)222581 035 $a(MiAaPQ)EBC31866516 035 $a(Au-PeEL)EBL31866516 035 $a(EXLCZ)993780000000101696 100 $a20211006d1994 uy 0 101 0 $aeng 135 $aurunu||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLeukocyte-Depleted Blood Products / $f editors, T.A. Lane, G. Myllylä 205 $a1st ed. 210 $aBasel : $cS. Karger, $d1994 215 $a1 online resource (VIII + 150 pages) : $c 7 figures, 19 tables 225 1 $aIssn Series 311 08$a9783805558624 311 08$a3805558627 327 $a978-3-8055-5862-4_Cover -- 978-3-8055-5862-4_00I -- 978-3-8055-5862-4_001 -- 978-3-8055-5862-4_006 -- 978-3-8055-5862-4_018 -- 978-3-8055-5862-4_029 -- 978-3-8055-5862-4_041 -- 978-3-8055-5862-4_053 -- 978-3-8055-5862-4_064 -- 978-3-8055-5862-4_075 -- 978-3-8055-5862-4_089 -- 978-3-8055-5862-4_101 -- 978-3-8055-5862-4_111 -- 978-3-8055-5862-4_123 -- 978-3-8055-5862-4_134 -- 978-3-8055-5862-4_145. 410 0$aIssn Series 606 $aHematology 606 $aImmunology 606 $aImmunosuppression 606 $aInfectious Diseases 606 $aPediatrics 606 $aSurgery 606 $aTransfusion Medicine 615 14$aHematology 615 24$aImmunology 615 24$aImmunosuppression 615 24$aInfectious Diseases 615 24$aPediatrics 615 24$aSurgery 615 24$aTransfusion Medicine 676 $a615/.39 700 $aLane$b T.A 701 0$aLane$b T. A$g(Thomas A.)$01234299 701 0$aMyllyla?$b G$g(Gunnar),$f1935-$01234300 801 0$bUKSKG 801 1$bUKSKG 906 $aBOOK 912 $a9910157659003321 996 $aLeukocyte-Depleted Blood Products$92867145 997 $aUNINA LEADER 05488nam 22008415 450 001 9910298458503321 005 20200702141154.0 010 $a3-319-22117-5 024 7 $a10.1007/978-3-319-22117-5 035 $a(CKB)4340000000000008 035 $a(SSID)ssj0001583818 035 $a(PQKBManifestationID)16263610 035 $a(PQKBTitleCode)TC0001583818 035 $a(PQKBWorkID)14864774 035 $a(PQKB)11363346 035 $a(DE-He213)978-3-319-22117-5 035 $a(MiAaPQ)EBC6315735 035 $a(MiAaPQ)EBC5588332 035 $a(Au-PeEL)EBL5588332 035 $a(OCoLC)932002609 035 $a(PPN)190532017 035 $a(EXLCZ)994340000000000008 100 $a20151106d2015 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFundamentals of Neurodegeneration and Protein Misfolding Disorders /$fby Martin Beckerman 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (XXII, 378 p. 122 illus., 103 illus. in color.) 225 1 $aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a3-319-22116-7 327 $aIntroduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer?s Disease -- Parkinson?s Disease -- Huntington?s Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. 330 $aThis unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer?s disease and Parkinson?s disease to Huntington?s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today?s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering. 410 0$aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 606 $aNeurosciences 606 $aBiophysics 606 $aBiophysics 606 $aProteins 606 $aBiomedical engineering 606 $aNeurology 606 $aPharmaceutical chemistry 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 615 0$aNeurosciences. 615 0$aBiophysics. 615 0$aBiophysics. 615 0$aProteins. 615 0$aBiomedical engineering. 615 0$aNeurology. 615 0$aPharmaceutical chemistry. 615 14$aNeurosciences. 615 24$aBiological and Medical Physics, Biophysics. 615 24$aProtein Science. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aNeurology. 615 24$aMedicinal Chemistry. 676 $a616.3995 700 $aBeckerman$b Martin$4aut$4http://id.loc.gov/vocabulary/relators/aut$0602888 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298458503321 996 $aFundamentals of Neurodegeneration and Protein Misfolding Disorders$92517632 997 $aUNINA