LEADER 05037nam 22007695 450 001 9910298457803321 005 20200702180455.0 010 $a3-319-19920-X 024 7 $a10.1007/978-3-319-19920-7 035 $a(CKB)4340000000000006 035 $a(SSID)ssj0001583819 035 $a(PQKBManifestationID)16263919 035 $a(PQKBTitleCode)TC0001583819 035 $a(PQKBWorkID)14865013 035 $a(PQKB)11211812 035 $a(DE-He213)978-3-319-19920-7 035 $a(MiAaPQ)EBC6315404 035 $a(MiAaPQ)EBC5588246 035 $a(Au-PeEL)EBL5588246 035 $a(OCoLC)932167711 035 $a(PPN)190517573 035 $a(EXLCZ)994340000000000006 100 $a20151127d2015 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFundamentals of Protein Structure and Function /$fby Engelbert Buxbaum 205 $a2nd ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (XVI, 521 p. 246 illus., 223 illus. in color.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a3-319-19919-6 327 $aPart I: Proteins -- Amino Acids -- Protein Structure -- Proteins in the Lab -- Part II: Enzymes -- Enzymes are Biocatalysts -- Enzyme Kinetics and Mechanism -- Inhibition and Inactivation of Enzymes -- Hæmyoglobin and Myoglobin: Cooperativity -- Enzyme Kinetics: Special Cases -- The Flow of Metabolites through Metabolic Pathways -- Part III: Special Proteins -- Protein Folding Diseases -- Immunoproteins -- Cell Skeleton -- Motor Proteins and Movement -- Cell-cell interactions -- Aiding in Folding: Molecular Chaperones and Chaperonins -- Part IV: Membrane Transport -- Protein Transport across Membranes -- Vesicular Transport in Eukaryotic Cells -- Transport of Solutes across Membranes -- Appendices. 330 $aThis book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion of how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological, and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments, and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure, and molecular interactions. The book emphasises the link between protein structure, physiological function, and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine, and related courses. About the author: Dr. Buxbaum is a biochemist with an interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities. 606 $aBiochemistry 606 $aCytology 606 $aChemistry 606 $aMedicine 606 $aBiophysics 606 $aBiophysics 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aChemistry/Food Science, general$3https://scigraph.springernature.com/ontologies/product-market-codes/C00004 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 615 0$aBiochemistry. 615 0$aCytology. 615 0$aChemistry. 615 0$aMedicine. 615 0$aBiophysics. 615 0$aBiophysics. 615 14$aBiochemistry, general. 615 24$aCell Biology. 615 24$aChemistry/Food Science, general. 615 24$aBiomedicine, general. 615 24$aBiological and Medical Physics, Biophysics. 676 $a572.633 700 $aBuxbaum$b Engelbert$4aut$4http://id.loc.gov/vocabulary/relators/aut$01061033 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298457803321 996 $aFundamentals of Protein Structure and Function$92517217 997 $aUNINA