LEADER 05428nam 22006975 450 001 9910298452803321 005 20250609110101.0 010 $a3-319-21082-3 024 7 $a10.1007/978-3-319-21082-7 035 $a(CKB)3710000000498910 035 $a(EBL)4091093 035 $a(SSID)ssj0001583903 035 $a(PQKBManifestationID)16265651 035 $a(PQKBTitleCode)TC0001583903 035 $a(PQKBWorkID)14865250 035 $a(PQKB)11524104 035 $a(DE-He213)978-3-319-21082-7 035 $a(MiAaPQ)EBC4091093 035 $a(PPN)19053625X 035 $a(MiAaPQ)EBC6237192 035 $a(EXLCZ)993710000000498910 100 $a20151031d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStem Cells in the Lung $eDevelopment, Repair and Regeneration /$fedited by Ivan Bertoncello 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (366 p.) 225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8985 300 $aDescription based upon print version of record. 311 08$a3-319-21081-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPart 1. Fetal Lung Development -- The Regulation of Branching Morphogenesis in the Developing Lung -- Epithelial-Mesenchymal Crosstalk in Lung Development -- Lung Vasculogenesis and Angiogenesis -- Neural Regulation of Lung Development -- Fetal and Neonatal Origins of Lung Disease -- Part 2. Adult Lung Stem and Progenitor Cells -- Stem and Progenitor Cells of the Trachea and Proximal Airways -- Stem and Progenitor Cells of the Distal Bronchiolar Airways -- Regenerative Cells in the Ageing Lung -- Part 3. Regulation of Lung Regeneration and Repair -- Stromal Regulation of Lung Regeneration and Repair -- Immunomodulatory Regulation Of Lung Regeneration and Repair -- Extracellular Matrix Specification of Regenerative Cells in the Adult Lung -- Role of Mechanical Stress in Lung Repair and Regeneration -- Part 4. Cellular Therapies for Lung Disease -- Cellular Origins of Fibrotic Lung Diseases -- Mesenchymal Stromal Cell Based Therapies for Lung Disease -- Lung Vascular Regeneration and Repair -- Directed Differentiation of Human Pluripotent Stem Cells into Lung and Airway Epithelial Cells -- Part 5. Bioengineering the Lung -- Regenerating the Respiratory Tract -- Acellular Lung Scaffolds in Lung Bioengineering -- Part 6. Afterword.-Prospects and Challenges in Lung Regenerative Medicine. 330 $aThis comprehensive overview of endogenous lung stem and progenitor cell organization and regulation in fetal lung development, postnatal lung growth and adulthood deftly compiles and explores the current body of research. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine. The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. All of the contributors are working at the cutting edge of the lung stem cell field, making Stem Cells in the Lung essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians. 410 0$aStem Cell Biology and Regenerative Medicine,$x2196-8985 606 $aStem cells 606 $aRegenerative medicine 606 $aTissue engineering 606 $aRespiratory organs?Diseases 606 $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010 606 $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080 606 $aPneumology/Respiratory System$3https://scigraph.springernature.com/ontologies/product-market-codes/H33134 615 0$aStem cells. 615 0$aRegenerative medicine. 615 0$aTissue engineering. 615 0$aRespiratory organs?Diseases. 615 14$aStem Cells. 615 24$aRegenerative Medicine/Tissue Engineering. 615 24$aPneumology/Respiratory System. 676 $a616.02774 702 $aBertoncello$b Ivan$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298452803321 996 $aStem Cells in the Lung$92519137 997 $aUNINA