LEADER 03160nam 22005775 450 001 9910298452503321 005 20200707020011.0 010 $a3-662-46943-X 024 7 $a10.1007/978-3-662-46943-9 035 $a(CKB)3710000000434397 035 $a(EBL)2096872 035 $a(SSID)ssj0001525059 035 $a(PQKBManifestationID)11900753 035 $a(PQKBTitleCode)TC0001525059 035 $a(PQKBWorkID)11496143 035 $a(PQKB)10584006 035 $a(DE-He213)978-3-662-46943-9 035 $a(MiAaPQ)EBC2096872 035 $a(PPN)186400381 035 $a(EXLCZ)993710000000434397 100 $a20150619d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPrinciples of Safety Pharmacology$b[electronic resource] /$fedited by Michael K. Pugsley, Michael J Curtis 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (477 p.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v229 300 $aDescription based upon print version of record. 311 $a3-662-46942-1 320 $aIncludes bibliographical references and index. 327 $aPreface -- Part 1. An Overview of Safety Pharmacology and its Role in Drug Discovery -- Part 2. The Safety Pharmacology Core Battery -- Part 3. Supplemental Safety Pharmacology -- Part 4. Safety Pharmacology of Biological and Anticancer Pharmaceuticals -- Part 5. Clinical Safety Pharmacology. 330 $aThis book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v229 606 $aPharmaceutical technology 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 615 0$aPharmaceutical technology. 615 14$aPharmaceutical Sciences/Technology. 676 $a344.04233 702 $aPugsley$b Michael K$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCurtis$b Michael J$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298452503321 996 $aPrinciples of safety pharmacology$91383050 997 $aUNINA