LEADER 03899nam  22006495  450 
001 9910298451203321
005 20200706082314.0
010   $a3-658-10161-X
024 7 $a10.1007/978-3-658-10161-9
035   $a(CKB)3710000000422066
035   $a(EBL)2094898
035   $a(SSID)ssj0001525078
035   $a(PQKBManifestationID)11820631
035   $a(PQKBTitleCode)TC0001525078
035   $a(PQKBWorkID)11486613
035   $a(PQKB)10068212
035   $a(DE-He213)978-3-658-10161-9
035   $a(MiAaPQ)EBC2094898
035   $a(PPN)186396511
035   $a(EXLCZ)993710000000422066
100   $a20150603d2015      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aReal-Time Monitoring of Cancer Cell Metabolism for Drug Testing$b[electronic resource] /$fby Hamed Alborzinia
205   $a1st ed. 2015.
210  1$aWiesbaden :$cSpringer Fachmedien Wiesbaden :$cImprint: Springer Spektrum,$d2015.
215   $a1 online resource (160 p.)
225 0 $aResearch
300   $aDescription based upon print version of record.
311   $a3-658-10160-1 
320   $aIncludes bibliographical references.
327   $aDrug Screening with New Perspectives -- Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip -- Anticancer Agents ? Effects Measured in Real Time -- Metabolism of Cancer Cells.
330   $aHamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.  Contents Drug Screening with New Perspectives Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip Anticancer Agents ? Effects Measured in Real Time Metabolism of Cancer Cells  Target Groups Researchers and students in the fields of biotechnology and pharmacy The Author Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.
606   $aCancer research
606   $aPharmacology
606   $aMedicinal chemistry
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000
615  0$aCancer research.
615  0$aPharmacology.
615  0$aMedicinal chemistry.
615 14$aCancer Research.
615 24$aPharmacology/Toxicology.
615 24$aMedicinal Chemistry.
676   $a610
676   $a614.5999
676   $a615
676   $a615.19
700   $aAlborzinia$b Hamed$4aut$4http://id.loc.gov/vocabulary/relators/aut$01060219
906   $aBOOK
912   $a9910298451203321
996   $aReal-Time Monitoring of Cancer Cell Metabolism for Drug Testing$92511885
997   $aUNINA