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010   $a3-319-08717-7
024 7 $a10.1007/978-3-319-08717-7
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035   $a(EBL)3568369
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035   $a(PQKBManifestationID)16140851
035   $a(PQKBTitleCode)TC0001546630
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035   $a(DE-He213)978-3-319-08717-7
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035   $a(PPN)188455523
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100   $a20150813d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aADAMTS13 $eBiology and Disease /$fedited by George M. Rodgers
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (193 p.)
300   $aDescription based upon print version of record.
311   $a3-319-08716-9 
320   $aIncludes bibliographical references and index.
327   $a1. A13: Structure and function -- 2. A13: The von Willebrand factor cleaving protease -- 3. A13: Angiogenesis and other biologic activities -- 4. A13:  Assays -- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome) -- 6. Acquired A13 deficiency (TTP) -- 7. Related thrombotic microangiopathies -- 8. Future directions.
330   $aThis comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.   Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
606   $aProteomics
606   $aHematology
606   $aCell biology
606   $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X
606   $aHematology$3https://scigraph.springernature.com/ontologies/product-market-codes/H3307X
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aProteomics.
615  0$aHematology.
615  0$aCell biology.
615 14$aProteomics.
615 24$aHematology.
615 24$aCell Biology.
676   $a570
702   $aRodgers$b George M$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298450403321
996   $aADAMTS13$92528867
997   $aUNINA