LEADER 05851nam 22008055 450 001 9910298445903321 005 20220301185551.0 010 $a3-319-19096-2 024 7 $a10.1007/978-3-319-19096-9 035 $a(CKB)3710000000484439 035 $a(EBL)4178255 035 $a(SSID)ssj0001583905 035 $a(PQKBManifestationID)16265602 035 $a(PQKBTitleCode)TC0001583905 035 $a(PQKBWorkID)14865686 035 $a(PQKB)10650164 035 $a(DE-He213)978-3-319-19096-9 035 $a(MiAaPQ)EBC4178255 035 $a(PPN)190537361 035 $a(EXLCZ)993710000000484439 100 $a20150930d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStudies on Experimental Toxicology and Pharmacology /$fedited by Stephen M. Roberts, James P. Kehrer, Lars-Oliver Klotz 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2015. 215 $a1 online resource (496 p.) 225 1 $aOxidative Stress in Applied Basic Research and Clinical Practice,$x2197-7224 300 $aDescription based upon print version of record. 311 $a3-319-19095-4 320 $aIncludes bibligraphical references at the end of each chapters and index. 327 $aPart I. Toxicological Mechanisms and Evaluation of Oxidative Stress -- A historical perspective on oxidative stress and intracellular redox control -- An overview of free radicals as causes and consequences of toxicity -- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity -- Lipid oxidation -- Protein oxidation and toxicology -- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth? -- Glutathione and thiols -- Reactive oxygen species as initiators and mediators of cellular signaling processes -- Role of oxidative stress in the process of carcinogenesis -- Part II. Agents that produce toxicity ? mechanisms and therapeutic interventions -- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents -- Oxidative stress and ethanol toxicity -- Pharmaceutical agents -- Insecticides and herbicides -- Health effects of indoor air pollution due to cooking with biomass fuel -- Outdoor pollutants -- Oxidative Stress and the Inorganic Carcinogens -- UV-induced signaling: Role of reactive oxygen species -- Nanomaterials -- Chemical warfare agents -- Part III. Special topics -- On the biochemistry of antioxidants ? current aspects.-Prevention of age-related diseases ? Effects of antioxidant supplements -- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity ? a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging. -- Oxygen toxicity: From cough to convulsion -- Oxidative stress in reproductive toxicology -- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress -- Aquatic and marine biology. 330 $aThis book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers. 410 0$aOxidative Stress in Applied Basic Research and Clinical Practice,$x2197-7224 606 $aOxidative stress 606 $aPharmacology 606 $aApoptosis 606 $aEnvironmental health 606 $aToxicological Phenomena 606 $aOxidative Stress 606 $aPharmacological Phenomena 606 $aOxidative Stress$3https://scigraph.springernature.com/ontologies/product-market-codes/L16070 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 606 $aEnvironmental Health$3https://scigraph.springernature.com/ontologies/product-market-codes/U18005 615 0$aOxidative stress. 615 0$aPharmacology. 615 0$aApoptosis. 615 0$aEnvironmental health. 615 12$aToxicological Phenomena. 615 12$aOxidative Stress. 615 22$aPharmacological Phenomena. 615 14$aOxidative Stress. 615 24$aPharmacology/Toxicology. 615 24$aApoptosis. 615 24$aEnvironmental Health. 676 $a615.9 702 $aRoberts$b Stephen M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKehrer$b James P$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKlotz$b Lars-Oliver$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298445903321 996 $aStudies on Experimental Toxicology and Pharmacology$92498419 997 $aUNINA