LEADER 04540nam 22005415 450 001 9910298432703321 005 20200706195600.0 010 $a3-319-74259-0 024 7 $a10.1007/978-3-319-74259-5 035 $a(CKB)4100000004243587 035 $a(MiAaPQ)EBC5387402 035 $a(DE-He213)978-3-319-74259-5 035 $a(PPN)227405811 035 $a(EXLCZ)994100000004243587 100 $a20180504d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHereditary Colorectal Cancer $eGenetic Basis and Clinical Implications /$fedited by Laura Valle, Stephen B. Gruber, Gabriel Capellį 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (494 pages) 311 $a3-319-74258-2 320 $aIncludes bibliographical references and index. 327 $aPart1 : GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome -- The molecular basis of Lynch-like syndrome -- Constitutional mismatch repair deficiency -- Mismatch repair proficient hereditary non-polyposis colorectal cancer -- Genetic and environmental modifiers of risk in Lynch syndrome -- ADENOMATOUS POLYPOSIS SYNDROMES- Introduction -- Familial adenomatous polyposis -- Polymerase proofreading-associated polyposis -- MUTYH-associated polyposis -- NTHL1-associated polyposis -- Germline biallelic inactivation of MMR genes (with polyposis phenotype) -- Unexplained adenomatous polyposis -- HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome -- Juvenile polyposis syndrome -- PTEN-hamartoma tumor syndromes -- Other hamartomatous polyposis conditions -- HEREDITARY MIXED POLYPOSIS SYNDROME -- SERRATED POLYPOSIS SYNDROME -- Part2: GENETIC DIAGNOSTICS and CLINICAL MANAGEMENT -- Genetic testing in hereditary colorectal cancer -- Universal tumor screening for Lynch syndrome -- Classification of genetic variants. Prediction models for Lynch syndrome -- Surveillance guidelines for hereditary colorectal cancer syndromes -- Surgical management of hereditary colorectal cancer syndromes -- Chemoprevention in hereditary colorectal cancer syndromes -- Immunotherapy in hereditary colorectal cancer -- The Immune Biology of Microsatellite Unstable cancer -- Hereditary colorectal cancer: Immunotherapy approaches -- Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES -- Databases: intentions, capabilities and limitations -- The Colon Cancer Family Registry Cohort -- The Prospective Lynch Syndrome Database -- The InSiGHT Database: An example LOVD system -- The International Mismatch Repair Consortium. 330 $aThis book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues. 606 $aMedical genetics 606 $aOncology   606 $aCancer research 606 $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aMedical genetics. 615 0$aOncology  . 615 0$aCancer research. 615 14$aGene Function. 615 24$aOncology. 615 24$aCancer Research. 676 $a616.994347042 702 $aValle$b Laura$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGruber$b Stephen B$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCapellį$b Gabriel$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298432703321 996 $aHereditary Colorectal Cancer$92500538 997 $aUNINA