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010   $a981-13-1486-1
024 7 $a10.1007/978-981-13-1486-5
035   $a(CKB)4100000006675013
035   $a(MiAaPQ)EBC5528130
035   $a(DE-He213)978-981-13-1486-5
035   $a(PPN)230536719
035   $a(EXLCZ)994100000006675013
100   $a20180927d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aRole of Tyrosine Kinases in Gastrointestinal Malignancies /$fedited by Ganji Purnachandra Nagaraju
205   $a1st ed. 2018.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018.
215   $a1 online resource (249 pages)
311   $a981-13-1485-3 
327   $aChapter 1. 1. Overview of tyrosine kinases and their receptors in gastrointestinal malignancies-  -- Chapter 2. EGFR and Erb-B2R (HER2): their role in Esophagus cancer -- Chapter 3. HGFR and FGFR2: their role in progression and metastasis of Esophagus cancer -- Chapter 4. Role of Src and VEGF R tyrosine kinases in Esophagus cancer -- Chapter 5. HGF receptor tyrosine kinase in gastric cancer. - Chapter 6. The EGF/ErbB receptor family of tyrosine kinases in gastric cancer -- Chapter 7. Helicobacter pylori CagA protein: its role and interaction tyrosine kinases in gastric cancer -- Chapter 8. RON receptor tyrosine kinase in pancreatic cancer progression -- Chapter 9. EGFR and Cytoplasmic kinases Src targeting in pancreatic cancer -- Chapter 10. VEGF and PDGFR targeting in pancreatic cancer -- Chapter 11. c-KIT, and FLT-3: their role in Hepatocellular carcinoma -- Chapter 12. VEGFR, and PDGFR: their targeting in Liver Cancer -- Chapter 13. EGFR and FGFR in growth and metastasis of colorectal cancer -- Chapter 14. VEGFR, and PDGFR: their targeting in colorectal cancerm -- Chapter 15. Nano materials and their impact on tyrosine kinase on selected gastrointestinal malignancies -- Chapter 16. Tyrosine kinase inhibitors and their clinical prospective in gastrointestinal malignancies -- Chapter 17. Drug resistance against tyrosine kinase inhibitors in gastrointestinal malignancies -- Chapter 18. Tyrosine kinases: their expression, diagnostic, therapeutic and prognostic aspects in gastrointestinal cancers.
330   $aThe aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.
606   $aCancer$xResearch
606   $aHuman physiology
606   $aCytology
606   $aProteins
606   $aGene expression
606   $aOncology
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110
606   $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
615  0$aCancer$xResearch.
615  0$aHuman physiology.
615  0$aCytology.
615  0$aProteins.
615  0$aGene expression.
615  0$aOncology.
615 14$aCancer Research.
615 24$aHuman Physiology.
615 24$aCell Biology.
615 24$aReceptors.
615 24$aGene Expression.
615 24$aOncology.
676   $a612.01516
702   $aNagaraju$b Ganji Purnachandra$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298430703321
996   $aRole of Tyrosine Kinases in Gastrointestinal Malignancies$92500536
997   $aUNINA