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010   $a3-319-90284-9
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035   $a(DE-He213)978-3-319-90284-5
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100   $a20180604d2018      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aVoltage-gated Sodium Channels: Structure, Function and Channelopathies /$fedited by Mohamed Chahine
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (X, 450 p. 80 illus., 55 illus. in color.) 
225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v246
311   $a3-319-90283-0 
327   $aPreface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. .
330   $aThis book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
410  0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v246
606   $aPharmacology
606   $aHuman genetics
606   $aHuman physiology
606   $aProteins 
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050
615  0$aPharmacology.
615  0$aHuman genetics.
615  0$aHuman physiology.
615  0$aProteins .
615 14$aPharmacology/Toxicology.
615 24$aHuman Genetics.
615 24$aHuman Physiology.
615 24$aProtein Structure.
676   $a615
702   $aChahine$b Mohamed$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298430603321
996   $aVoltage gated sodium channels$91078369
997   $aUNINA