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001 9910298429303321
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010   $a981-13-0484-X
024 7 $a10.1007/978-981-13-0484-2
035   $a(PPN)229501257
035   $a(CKB)4100000005323298
035   $a(DE-He213)978-981-13-0484-2
035   $a(MiAaPQ)EBC5471996
035   $a(EXLCZ)994100000005323298
100   $a20180720d2018      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aHIV Vaccines and Cure $eThe Path Towards Finding an Effective Cure and Vaccine /$fedited by Linqi Zhang, Sharon R. Lewin
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018.
215   $a1 online resource (XV, 318 p. 21 illus., 16 illus. in color.)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1075
311 08$a981-13-0483-1 
327   $aHIV Vaccine Efficacy Trials: RV144 and beyond -- HIV T-cell vaccines -- HIV broadly neutralizing antibodies: VRC01 and beyond -- Structural features of broadly neutralizing antibodies and rational design of vaccine -- Monkey models and HIV vaccine research -- Treatment of HIV for the Prevention of Transmission in Discordant Couples and at the Population Level -- HIV persistence on antiretroviral therapy and barriers to a cure -- The molecular biology of HIV latency -- Cellular determinants of HIV persistence on antiretroviral therapy -- In Vitro and In Vivo Models of HIV Latency -- Measuring HIV persistence on antiretroviral therapy -- Clinical interventions in HIV cure research.
330   $aThis book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1075
606   $aMedical virology
606   $aVaccines
606   $aImmunology
606   $aLaboratory animals
606   $aVirology$3http://scigraph.springernature.com/things/product-market-codes/B22003
606   $aVaccine$3http://scigraph.springernature.com/things/product-market-codes/B16010
606   $aImmunology$3http://scigraph.springernature.com/things/product-market-codes/B14000
606   $aAnimal Models$3http://scigraph.springernature.com/things/product-market-codes/L25050
615  0$aMedical virology.
615  0$aVaccines.
615  0$aImmunology.
615  0$aLaboratory animals.
615 14$aVirology.
615 24$aVaccine.
615 24$aImmunology.
615 24$aAnimal Models.
676   $a616.9101
702   $aZhang$b Linqi$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aLewin$b Sharon$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298429303321
996   $aHIV Vaccines and Cure$92505679
997   $aUNINA