LEADER 01038nam0-22003611i-450- 001 990003792100403321 005 20031110113306.0 010 $a88-204-9884-7 035 $a000379210 035 $aFED01000379210 035 $a(Aleph)000379210FED01 035 $a000379210 100 $a20030910d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aCorrelazione e regressione$fGiuseppe A. Micheli, Piero Manfredi 205 $a2. ed. 210 $aMilano$cFranco Angeli$d1996 215 $a234 p.$ctab., fig.$d22 cm 225 1 $aMetodologia delle scienze umane$v6 610 0 $aSCIENZE SOCIALI$aRicerca$aMetodo statistico 676 $a300.72 676 $a300.1519537 676 $a300.1519536 700 1$aMicheli,$bGiuseppe A.$f<1948->$0116852 702 1$aManfredi,$bPiero 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003792100403321 952 $aAN 300.72 MIC 1$b6002$fBFS 959 $aBFS 996 $aCorrelazione e regressione$9506313 997 $aUNINA LEADER 04463nam 22005655 450 001 9910298425103321 005 20251113210643.0 010 $a981-10-7614-6 024 7 $a10.1007/978-981-10-7614-5 035 $a(CKB)4100000002485542 035 $a(DE-He213)978-981-10-7614-5 035 $a(MiAaPQ)EBC6312796 035 $a(MiAaPQ)EBC5591521 035 $a(Au-PeEL)EBL5591521 035 $a(OCoLC)1066187192 035 $a(PPN)224636812 035 $a(EXLCZ)994100000002485542 100 $a20180203d2018 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHuman Epigenomics /$fby Carsten Carlberg, Ferdinand Molnár 205 $a1st ed. 2018. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2018. 215 $a1 online resource (XIX, 223 p. 120 illus. in color.) 311 08$a981-10-7613-8 327 $aWhat is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics. . 330 $aThe term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule ?a picture tells more than thousand words?. The content of the book is based on the lecture course ?Molecular Medicine and Genetics? that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks ?Mechanisms of Gene Regulation? (ISBN 978-94-017-7741-4) and ?Nutrigenomics? (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecularbasis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine. 606 $aMedical genetics 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMedical Genetics 606 $aBiomedical Research 615 0$aMedical genetics. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aMedical Genetics. 615 24$aBiomedical Research. 676 $a616.042 700 $aCarlberg$b Carsten$4aut$4http://id.loc.gov/vocabulary/relators/aut$0849346 702 $aMolnár$b Ferdinand$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298425103321 996 $aHuman Epigenomics$92504021 997 $aUNINA