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010   $a981-10-5526-2
024 7 $a10.1007/978-981-10-5526-3
035   $a(CKB)3810000000358950
035   $a(DE-He213)978-981-10-5526-3
035   $a(MiAaPQ)EBC5446002
035   $a(PPN)22949188X
035   $a(EXLCZ)993810000000358950
100   $a20180628d2018      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDevelopmental Origins of Health and Disease (DOHaD) $eFrom Biological Basis to Clinical Significance /$fedited by Takeo Kubota, Hideoki Fukuoka
205   $a1st ed. 2018.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2018.
215   $a1 online resource (VII, 95 p. 23 illus., 16 illus. in color.) 
225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1012
311   $a981-10-5525-4 
327   $aPart 1 Biological Basis -- One carbon metabolism and lipid metabolism in DOHaD -- Novel models of epigenetic gene regulation in the nutritional environment -- Epigenetic switching and neonatal nutritional environment -- Part 2 Disease and environment -- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD) -- Fetal origins of hypertension -- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory -- Part 3 Transgenerational mechanism and its consequences -- Placental development and nutritional environment -- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm -- Part 4 Clinical Significance -- Preemptive epigenetic medicine based on fetal programming.
330   $aThis book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
410  0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1012
606   $aHuman physiology
606   $aReproductive health
606   $aDevelopmental biology
606   $aHuman Physiology
606   $aReproductive Medicine
606   $aDevelopmental Biology and Stem Cells
615  0$aHuman physiology.
615  0$aReproductive health.
615  0$aDevelopmental biology.
615 14$aHuman Physiology.
615 24$aReproductive Medicine.
615 24$aDevelopmental Biology and Stem Cells.
676   $a612
702   $aKubota$b Takeo$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aFukuoka$b Hideoki$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298422403321
996   $aDevelopmental Origins of Health and Disease (DOHaD)$92512265
997   $aUNINA