LEADER 04285nam 22004575 450 001 9910298421003321 005 20200706095701.0 010 $a981-10-8195-6 024 7 $a10.1007/978-981-10-8195-8 035 $a(CKB)4100000004244296 035 $a(MiAaPQ)EBC5401129 035 $a(DE-He213)978-981-10-8195-8 035 $a(PPN)227400283 035 $a(EXLCZ)994100000004244296 100 $a20180524d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Hair Fibre: Proteins, Structure and Development /$fedited by Jeffrey E. Plowman, Duane P. Harland, Santanu Deb-Choudhury 205 $a1st ed. 2018. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018. 215 $a1 online resource (224 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1054 311 $a981-10-8194-8 327 $aFibre Ultrastructure -- The Follicle Cycle in Brief -- Diversity of Trichocyte Keratins and Keratin -- Evolution of Trichocyte Keratins -- Evolution of Trichocyte Keratin Associated Proteins -- Structural Hierarchy of Trichocyte Keratin Intermediate Filaments -- Trichocyte Keratin-Associated Proteins (KAPs) -- Introduction to Hair Development -- Environment of the Anagen Follicle -- Development of Hair Fibres -- Macrofibril Formation -- Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins -- The Thermodynamics of Trichocyte Keratins -- Oxidative Modification of Trichocyte Keratins. 330 $aHair is a sophisticated bio-based material, whether it is on a human head or part of a mammalian coat. In particular, the role of the proteins in the follicle, integral to hair development, are not well understood. This new book seeks to integrate the latest research in proteomic and morphological studies into a coherent description of fibre development from the follicle to its final mature, keratinized form. To achieve this the book has been divided into three sections. The first describes the keratins, their associated proteins and how they assemble into intermediate filaments in the fibre. The second covers the latest information on the morphological changes that occur from the base of the follicle, through the keratinization process to the mature fibre and the role that proteins play in this. The final section delves into fundamental fibre properties such as crosslinking, thermal and oxidative modifications and how these affect the mature fibre. The editors of this book are internationally recognised for their work in the area of mammalian hair, Jeffrey Plowman for his knowledge of the proteomics of the fibre, Santanu Deb-Choudhury for his work in the area of crosslinking in the fibre and Duane Harland for his understanding of the morphological development of the fibre. Together they have collected material from other international experts: Leopold Eckhart and Florian Ehrlich for their knowledge of the evolution of keratins; Dong Dong Wu and David Irwin for their studies on keratin associated protein evolution; David Parry and Bruce Fraser for their work on keratin and keratin associated protein structure and assembly; John McKinnon for his studies on macrofibril formation; Crisan Popescu for the thermodynamics of keratins; and Jolon Dyer for his oxidative modification studies of keratins. This book provides a comprehensive introduction, and useful reference guide to hair biology and will be of interest to both scientists and technologists. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1054 606 $aHuman physiology 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 615 0$aHuman physiology. 615 14$aHuman Physiology. 676 $a612.799 702 $aPlowman$b Jeffrey E$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHarland$b Duane P$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDeb-Choudhury$b Santanu$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298421003321 996 $aThe Hair Fibre: Proteins, Structure and Development$92522671 997 $aUNINA