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010   $a981-13-0002-X
024 7 $a10.1007/978-981-13-0002-8
035   $a(CKB)4100000004244343
035   $a(MiAaPQ)EBC5407231
035   $a(DE-He213)978-981-13-0002-8
035   $a(PPN)227401034
035   $a(EXLCZ)994100000004244343
100   $a20180531d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aGlucose-sensing Receptor in Pancreatic Beta-cells /$fedited by Itaru Kojima
205   $a1st ed. 2018.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018.
215   $a1 online resource (73 pages)
311   $a981-13-0001-1 
327   $a1 HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR  -- 2 Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells  -- 3 KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR  -- 4 Signaling System Activated by the Glucose-sensing Receptor -- 5 The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells.
330   $aSince the 1970s, there has been much discussion about the ?glucoreceptor? and ?substrate site? and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the ?glucoreceptor theory.? This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: ?glucoreceptor theory?. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. .
606   $aHuman physiology
606   $aEndocrinology 
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053
615  0$aHuman physiology.
615  0$aEndocrinology .
615 14$aHuman Physiology.
615 24$aEndocrinology.
676   $a573.377
702   $aKojima$b Itaru$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298420003321
996   $aGlucose-sensing Receptor in Pancreatic Beta-cells$92503037
997   $aUNINA