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010   $a3-319-69042-6
024 7 $a10.1007/978-3-319-69042-1
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035   $a(MiAaPQ)EBC5344829
035   $a(DE-He213)978-3-319-69042-1
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100   $a20180409d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aHeat Shock Proteins in the Immune System /$fedited by Robert J. Binder, Pramod K. Srivastava
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (186 pages)
311   $a3-319-69040-X 
327   $aIntroduction and history.- Part I: Structure of the HSPs in relation to chaperoning peptides and proteins -- Chapter 1: Hsp70-subsrate interactions -- Chapter 2: Molecular Chaperone Inhibitors.- Part II: Exposure of HSPs to immune cells -- Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals.- Part III: Regulation of immune responses by extracellular HSPs -- Chapter 4: The Heat Shock Protein-CD91 pathway and Tumor Immuno-surveillance -- Chapter 5: Bridging the gaps in the vaccine development: Avant-garde vaccine approach with secreted heat shock protein gp96-Ig -- Chapter 6: Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones -- Chapter 7: Heat shock protein mediated T cell responses in pathogen infections -- Chapter 8: An ancestral immune surveillance system in the amphibian Xenopus connecting certain heat shock proteins with classical and nonclassical MHC class I molecules -- Chapter 9: Inhibition of HSPs for Enhanced Immunity.     .
330   $aExperts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.  .
606   $aImmunology
606   $aProteins
606   $aInfectious diseases
606   $aCancer$xResearch
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040
606   $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aImmunology.
615  0$aProteins.
615  0$aInfectious diseases.
615  0$aCancer$xResearch.
615 14$aImmunology.
615 24$aProtein Science.
615 24$aInfectious Diseases.
615 24$aCancer Research.
676   $a572.6
702   $aBinder$b Robert J$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aSrivastava$b Pramod K$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298412403321
996   $aHeat Shock Proteins in the Immune System$92526733
997   $aUNINA