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010   $a3-319-98146-3
024 7 $a10.1007/978-3-319-98146-8
035   $a(CKB)4100000006999237
035   $a(MiAaPQ)EBC5541228
035   $a(DE-He213)978-3-319-98146-8
035   $a(PPN)231462069
035   $a(EXLCZ)994100000006999237
100   $a20181006d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAutophagy in Health and Disease $ePotential Therapeutic Approaches /$fedited by Kursad Turksen
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2018.
215   $a1 online resource (182 pages)
225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8985
311   $a3-319-98145-5 
327   $aAutophagy and Stem cells -- Fine-Tuning the Stem Cell Fate by Autophagy -- Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine -- Forkhead box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis -- The Role of mTOR in Osteoclasts -- Apoptotic Cell Clearance in Gut Tissue-Role of Intestinal Regeneration -- Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration -- The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response -- Emerging Connections: Presynaptic Autophagy in Brain Aging and Neurodegenerative Diseases -- Virus and Autophagy: Enemies or Allies -- Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives.
330   $aThis timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
410  0$aStem Cell Biology and Regenerative Medicine,$x2196-8985
606   $aCell cycle
606   $aCell physiology
606   $aPharmaceutical technology
606   $aMetabolic diseases
606   $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030
606   $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010
606   $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010
606   $aMetabolic Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33118
615  0$aCell cycle.
615  0$aCell physiology.
615  0$aPharmaceutical technology.
615  0$aMetabolic diseases.
615 14$aCell Cycle Analysis.
615 24$aCell Physiology.
615 24$aPharmaceutical Sciences/Technology.
615 24$aMetabolic Diseases.
676   $a571.936
702   $aTurksen$b Kursad$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298411803321
996   $aAutophagy in Health and Disease$92522661
997   $aUNINA