LEADER 04291nam 22004575 450 001 9910298410703321 005 20200706030217.0 010 $a3-319-98164-1 024 7 $a10.1007/978-3-319-98164-2 035 $a(CKB)4100000006995919 035 $a(MiAaPQ)EBC5529505 035 $a(DE-He213)978-3-319-98164-2 035 $a(PPN)230542425 035 $a(EXLCZ)994100000006995919 100 $a20180929d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Basis of Resilience $eAdapting to a Changing Environment /$fby Patrick L. Iversen 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (325 pages) 311 $a3-319-98163-3 327 $aPrologue -- Preface -- Social Entropy -- Virus among Us -- Non-linear Anomalies -- Bacterial Infectious Disease -- Cure 2000 -- Chemicals in the Environment -- Immune Defense -- Metabolic Defense -- Analog Genetics -- Eteplirsen -- Regulating Resilience. 330 $aThis book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in ?nonlinear anomalies.? An example includes medical countermeasures for Ebola and Marburg viruses under the ?Animal Rule.? Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question ?what informs molecular mechanisms of resilience?? that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience. 606 $aPharmacology 606 $aMolecular biology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aPharmacology. 615 0$aMolecular biology. 615 14$aPharmacology/Toxicology. 615 24$aMolecular Medicine. 676 $a579.25 700 $aIversen$b Patrick L$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062082 906 $aBOOK 912 $a9910298410703321 996 $aMolecular Basis of Resilience$92522659 997 $aUNINA