LEADER 04491nam 22006015 450 001 9910298408103321 005 20251116203505.0 010 $a3-319-97421-1 024 7 $a10.1007/978-3-319-97421-7 035 $a(CKB)4100000006674651 035 $a(MiAaPQ)EBC5521333 035 $a(DE-He213)978-3-319-97421-7 035 $a(PPN)230542905 035 $a(EXLCZ)994100000006674651 100 $a20180920d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCardiac Extracellular Matrix $eFundamental Science to Clinical Applications /$fedited by Eric G. Schmuck, Peiman Hematti, Amish N. Raval 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (252 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1098 311 08$a3-319-97420-3 327 $aPreface -- Biomechanical Properties and Mechanobiology of Cardiac ECM -- Imaging the Cardiac Extracellular Matrix -- Animal Models and Cardiac Extracellular Matrix Research -- Applications of Cardiac Extracellular Ma-trix in Tissue Engineering and Regenera-tive Medicine -- Whole Cardiac Tissue Bioscaffolds -- Natural Sources of Extracellular Matrix for Cardiac Repair -- Cardiac Extracellular Matrix Modification as a Therapeutic Approach -- Extracellular Matrix for Myocardial Repair -- Role of Extracellular Matrix in Cardiac Cellular Therapies -- Regulation of Regenerative Medicine Products -- Clinical Trial Design for Investigational Cardio-Regenerative Therapy -- Regenerative Medicine Venturing at the University-Industry Boundary: Implications for Institutions, Entrepreneurs, and Industry -- Index. 330 $aThis book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM?s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1098 606 $aCytology 606 $aCardiology 606 $aBiomedical engineering 606 $aHeart$xSurgery 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 606 $aCardiac Surgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H59028 615 0$aCytology. 615 0$aCardiology. 615 0$aBiomedical engineering. 615 0$aHeart$xSurgery. 615 14$aCell Biology. 615 24$aCardiology. 615 24$aBiomedical Engineering/Biotechnology. 615 24$aCardiac Surgery. 676 $a611.0182 702 $aSchmuck$b Eric G.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHematti$b Peiman$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRaval$b Amish N.$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298408103321 996 $aCardiac Extracellular Matrix$92494387 997 $aUNINA