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100   $a20180705d2018      u|         0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAcute Neuronal Injury $eThe Role of Excitotoxic Programmed Cell Death Mechanisms /$fedited by Denson G. Fujikawa
205   $a2nd ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (212 pages)
311   $a3-319-77494-8 
327   $aIntroduction -- Excitotoxic programmed cell death involves caspase-independent mechanisms -- To survive or to die: how neurons deal with it -- Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches -- Mitochondrial damage in traumatic CNS injury -- Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury -- Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia -- Apoptosis-inducing factor translocation to nuclei after transient global ischemia -- Necroptosis in cerebral ischemia -- Histological and elemental changes in ischemic stroke -- Hypoglycemic brain damage -- Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis -- Conclusion.
330   $aAn overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
606   $aNeurosciences
606   $aNeurology
606   $aPathology
606   $aCytology
606   $aNeurobiology
606   $aPsychiatry
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001
606   $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066
606   $aPsychiatry$3https://scigraph.springernature.com/ontologies/product-market-codes/H53003
615  0$aNeurosciences.
615  0$aNeurology.
615  0$aPathology.
615  0$aCytology.
615  0$aNeurobiology.
615  0$aPsychiatry.
615 14$aNeurosciences.
615 24$aNeurology.
615 24$aPathology.
615 24$aCell Biology.
615 24$aNeurobiology.
615 24$aPsychiatry.
676   $a616.8
702   $aFujikawa$b Denson G$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298405003321
996   $aAcute Neuronal Injury$92522653
997   $aUNINA