LEADER 05318nam 22006975 450 001 9910298403203321 005 20230810194515.0 010 $a3-319-92967-4 024 7 $a10.1007/978-3-319-92967-5 035 $a(CKB)4100000006098319 035 $a(MiAaPQ)EBC5504881 035 $a(DE-He213)978-3-319-92967-5 035 $a(PPN)229917453 035 $a(EXLCZ)994100000006098319 100 $a20180829d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSystems Biology /$fedited by Nikolaus Rajewsky, Stefan Jurga, Jan Barciszewski 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (404 pages) 225 1 $aRNA Technologies,$x2197-9758 311 $a3-319-92966-6 327 $aChapter 1: Systems Biology of Genome Structure and Dynamics -- Chapter 2: A Systems Perspective of Complex Diseases: from Reductionism to Integration -- Chapter 3: Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems -- Chapter 4: Systems Biology of RNA Binding Proteins in Amyotrophic Lateral Sclerosis -- Chapter 5: Systems Approaches to Map in vivo RNA-Protein Interactions in Arabidopsis thaliana -- Chapter 6: Systems-Level Analysis of Bacterial Regulatory Small RNA Networks -- Chapter 7: Epioncogenes in Cancer?Identification of Transcriptomic and Epigenomic Cooperation Networks by Multi-Omics Integration of RNA-Seq and ChIP-Seqdata -- Chapter 8: Coupling Large Scale ?Omics Data for Deciphering Systems Complexity -- Chapter 9: Deciphering the Universe of RNA Structures and tTans RNA-RNA Interactions of Transcriptomes in vivo / from Experimental Protocols to Computational Analyses -- Chapter 10: Is Autogenous Post-Transcriptional Gene Regulation Common? -- Chapter 11: The Interplay of Non-Coding RNAs and X Chromosome Inactivation in Human Disease -- Chapter 12: Novel Insights of the Gene Translational Dynamic and Complex Revealed by Ribosome Profiling -- Chapter 13: Biophysical Analysis of MiRNA-Dependent Gene Regulation -- Chapter 14: Modeling and Analyzing the Flow of Molecular Machines in Gene Expression -- Chapter 15: Robust Approaches to Generating Reliable Predictive Models in Systems Biology -- Chapter 16: Hints from Information Theory for Analyzing Dynamic & High Dimensional Biological Data -- Chapter 17: Enhancing Metabolic Models with Genome-Scale Experimental Data -- Chapter 18: An Integrative MuSiCO Algorithm: from the Patient-Specific Transcriptional Profiles to Novel Checkpoints in Disease Pathobiology -- Chapter 19: Nanocellulose: a New Multifunctional Tool for RNA System Biology Research. 330 $aMany breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described. The chapter ?Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses? is available open access under a CC BY 4.0 license via link.springer.com. 410 0$aRNA Technologies,$x2197-9758 606 $aBioinformatics 606 $aMedical genetics 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aBiomaterials 606 $aNucleic acids 606 $aBiotechnology 606 $aComputational and Systems Biology 606 $aMedical Genetics 606 $aBiomedical Research 606 $aNucleic Acid 606 $aBiotechnology 615 0$aBioinformatics. 615 0$aMedical genetics. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aBiomaterials. 615 0$aNucleic acids. 615 0$aBiotechnology. 615 14$aComputational and Systems Biology. 615 24$aMedical Genetics. 615 24$aBiomedical Research. 615 24$aNucleic Acid. 615 24$aBiotechnology. 676 $a570.113 702 $aRajewsky$b Nikolaus$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aJurga$b Stefan$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBarciszewski$b Jan$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298403203321 996 $aSystems biology$91109756 997 $aUNINA