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100   $a20181102d2018      u|         0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aEscherichia coli, a Versatile Pathogen /$fedited by Gad Frankel, Eliora Z Ron
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (247 pages)
225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v416
311 08$a3-319-99663-0 
327   $aShigella and enteroinvasive Escherichia coli -- Enteroaggregative Escherichia coli -- The Type III Secretion System of pathogenic Escherichia coli -- Modulation of host cell processes by T3SS effectors -- The 2011 German enterohemorrhagic Escherichia coli O104:H4 outbreak ? the danger is still out there -- Extraintestinal Pathogenic Escherichia coli -- Pandemic bacteremic Escherichia coli strains: evolution and emergence of drug resistant pathogens -- Current Trends in Antimicrobial Resistance of Escherichia coli -- Vaccines against Escherichia coli.
330   $aEscherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
410  0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v416
606   $aMedical microbiology
606   $aDiseases
606   $aBacteria
606   $aMedical Microbiology
606   $aDiseases
606   $aBacteria
615  0$aMedical microbiology.
615  0$aDiseases.
615  0$aBacteria.
615 14$aMedical Microbiology.
615 24$aDiseases.
615 24$aBacteria.
676   $a589.95
702   $aFrankel$b Gad$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aRon$b Eliora Z.$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298395103321
996   $aEscherichia coli, a Versatile Pathogen$92503159
997   $aUNINA