LEADER 06192nam 22008055 450 001 9910298354003321 005 20200701160112.0 010 $a1-4614-8993-8 024 7 $a10.1007/978-1-4614-8993-1 035 $a(CKB)2550000001151684 035 $a(EBL)1538662 035 $a(SSID)ssj0001049030 035 $a(PQKBManifestationID)11623067 035 $a(PQKBTitleCode)TC0001049030 035 $a(PQKBWorkID)11033665 035 $a(PQKB)10523004 035 $a(MiAaPQ)EBC1538662 035 $a(DE-He213)978-1-4614-8993-1 035 $a(PPN)176100253 035 $a(EXLCZ)992550000001151684 100 $a20131024d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNanotoxicology $eMaterials, Methodologies, and Assessments /$fedited by Nelson Durán, Silvia S. Guterres, Oswaldo L. Alves 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (415 p.) 225 1 $aNanomedicine and Nanotoxicology,$x2194-0452 300 $aDescription based upon print version of record. 311 $a1-4614-8992-X 320 $aIncludes bibliographical references and index. 327 $aForeword -- Preface -- Chapter 1: Nanomaterials -- Chapter 2: Concepts and Methodology of Interaction of Carbon Nanostructures with Cellular Systems -- Chapter 3: Nanostability -- Chapter 4: Pharmacokinetics and Phamacodynamics of Nanomaterials -- Chapter 5: In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines -- Chapter 6: Carbon Nanotubes: From Synthesis to Genotoxicity -- Chapter 7: From Combinatorial Display Techniques to Microarray Technology: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedicines -- Chapter 8: Genetic Studies on the Effects of Nanomaterials -- Chapter 9: Cellular Mechanisms in Nanomaterial Internalization, Intracellular Trafficking and Toxicity -- Chapter 10: Cytotoxicity and Genotoxicity of Solid Lipid Nanoparticles -- Chapter 11: Cytotoxicity and Genotoxicity of Biogenically Synthesized Silver Nanoparticles -- Chapter 12: Cytotoxicity and Genotoxicity of Iron Oxides Nanoparticles -- Chapter 13: Poloxamers as Drug-Delivery Systems: Physico-Chemical, Pharmaceutical And Toxicological Aspects -- Chapter 14: Polymeric Nanoparticles: In Vivo Toxicological Evaluation, Cardiotoxicity and Hepatotoxicity -- Chapter 15: Cyto,Geno and Ecotoxicity of Copper Nanoparticles -- Chapter 16: Accessing the Erythrocyte Toxicity of Nanomaterials: From Current Methods to Biomolecular Surface Chemistry Interactions -- Index. 330 $aThis book takes a systematic approach to nanotoxicology and the developing risk factors associated with  nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures. Provides an introduction to nanostructures actually in use Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology. 410 0$aNanomedicine and Nanotoxicology,$x2194-0452 606 $aPharmacology 606 $aNanochemistry 606 $aEnvironmental toxicology 606 $aNanotechnology 606 $aNanoscience 606 $aNanoscience 606 $aNanostructures 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aNanochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C33000 606 $aEcotoxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/U25001 606 $aNanotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/Z14000 606 $aNanoscale Science and Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/P25140 615 0$aPharmacology. 615 0$aNanochemistry. 615 0$aEnvironmental toxicology. 615 0$aNanotechnology. 615 0$aNanoscience. 615 0$aNanoscience. 615 0$aNanostructures. 615 14$aPharmacology/Toxicology. 615 24$aNanochemistry. 615 24$aEcotoxicology. 615 24$aNanotechnology. 615 24$aNanoscale Science and Technology. 676 $a541.2 676 $a615.1/901 702 $aDurán$b Nelson$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGuterres$b Silvia S$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aAlves$b Oswaldo L$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298354003321 996 $aNanotoxicology$92052322 997 $aUNINA