LEADER 06613nam 22007815 450 001 9910298352703321 005 20200630012233.0 010 $a1-4899-8032-6 024 7 $a10.1007/978-1-4899-8032-8 035 $a(CKB)3710000000089071 035 $a(EBL)1698079 035 $a(OCoLC)881166050 035 $a(SSID)ssj0001185879 035 $a(PQKBManifestationID)11675868 035 $a(PQKBTitleCode)TC0001185879 035 $a(PQKBWorkID)11229777 035 $a(PQKB)11359647 035 $a(MiAaPQ)EBC1698079 035 $a(DE-He213)978-1-4899-8032-8 035 $a(PPN)17674973X 035 $a(EXLCZ)993710000000089071 100 $a20140222d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCancer Biology and the Nuclear Envelope$b[electronic resource] $eRecent Advances May Elucidate Past Paradoxes /$fedited by Eric C. Schirmer, Jose I. de las Heras 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (610 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v773 300 $aDescription based upon print version of record. 311 $a1-4899-8031-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aSection I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective -- Cancer and the nuclear envelope, a history and perspective -- The role of the nuclear lamina in cancer and apoptosis -- The diagnostic pathology of the nuclear envelope in human cancers -- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer -- "To be or not to be in good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer -- Section II: The nuclear envelope in cell cycle regulation and signaling -- pRb and lamins in cell cycle regulation and aging -- Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology -- NETs and cell cycle regulation -- Nuclear envelope regulation of signaling cascades -- Section III: Nuclear envelope regulation of the genome -- Nuclear envelope - connecting structural genome organization to regulation of gene expression -- Studying lamins in invertebrate models -- Lamin organization of chromosome positioning -- Section IV: Functions of the NPC in cancer -- NPC proteins linked in cancer overview -- Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis -- Wnt signaling proteins associate with the nuclear pore complex: implications for cancer -- Section V: The nuclear envelope in DNA damage and stress responses -- DNA damage and lamins -- Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression -- Lamines and oxygen stress damage in cell proliferation.- Section VI: The nuclear envelope link to cell migration and metastasis -- Nuclear mechanics in cancer -- Nuclear envelope in nuclear positioning and cell migration -- Nesprins in cell stability and migration -- Connecting the nucleus to the cytoskeleton for nuclear positioning and call migration -- Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope -- Nuclear envelope invaginations and cancer -- Mechanisms of nuclear size regulation in model systems and cancer -- Control of nuclear size by NPC proteins -- Do lamins influence disease progression in cancer?.   . 330 $a"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE  is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.". 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v773 606 $aCancer research 606 $aMedical microbiology 606 $aProteins  606 $aCell membranes  606 $aMedicine 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aCancer research. 615 0$aMedical microbiology. 615 0$aProteins . 615 0$aCell membranes . 615 0$aMedicine. 615 14$aCancer Research. 615 24$aMedical Microbiology. 615 24$aProtein Science. 615 24$aMembrane Biology. 615 24$aBiomedicine, general. 676 $a616.99407 702 $aSchirmer$b Eric C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $ade las Heras$b Jose I$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298352703321 996 $aCancer Biology and the Nuclear Envelope$92511879 997 $aUNINA