LEADER 05157nam 22006375 450 001 9910298352103321 005 20200703215134.0 010 $a1-4939-1598-3 024 7 $a10.1007/978-1-4939-1598-9 035 $a(CKB)3710000000291286 035 $a(EBL)1968644 035 $a(OCoLC)896824888 035 $a(SSID)ssj0001385802 035 $a(PQKBManifestationID)11994423 035 $a(PQKBTitleCode)TC0001385802 035 $a(PQKBWorkID)11349390 035 $a(PQKB)11165203 035 $a(MiAaPQ)EBC1968644 035 $a(DE-He213)978-1-4939-1598-9 035 $a(PPN)18309140X 035 $a(EXLCZ)993710000000291286 100 $a20141121d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAmorphous Solid Dispersions $eTheory and Practice /$fedited by Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (702 p.) 225 1 $aAdvances in Delivery Science and Technology,$x2192-6204 300 $aDescription based upon print version of record. 311 $a1-4939-1597-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1 Fundamentals of Amorphous Systems:  Thermodynamic Aspects -- 2 Theoretical Considerations in Developing Amorphous Solid Dispersions -- 3 Overview of Amorphous Solid Dispersion Technologies -- 4 Excipients for Amorphous Solid Dispersions -- 5 Miniaturized Screening Tools for Polymer and Process Evaluation -- 6 HME for Solid Dispersions: Composition and Design Considerations -- 7 HME for Solid Dispersions: Scale up and Late Stage Development -- 8 Spray Drying: Scale UP and Manufacturing -- 9 Design and Development of HPMCAS based spray dried dispersions -- 10 MBP Technology: Composition and Design Considerations -- 11 MBP Technology: Process Development and Scale up -- 12 Pharmaceutical Development of MBP Solid Dispersions: Case Studies -- 13 Downstream Processing Considerations -- 14 Structural Characterization of Amorphous Solid Dispersions -- 15 Dissolution of Amorphous Solid Dispersions: Theory and Practice -- 16 Stability of Amorphous Solid Dispersion -- 17 Regulatory Considerations in Development of Amorphous Solid Dispersions -- 18 KinetiSol® based Amorphous Solid Dispersions -- 19 Amorphous Solid Dispersion Using Supercritical Fluid Technology -- 20 Supersolubilization by Using Non-Salt Forming Acid-Base Interaction -- 21 Stabilized Amorphous Solid Dispersions with Small Molecule Excipients -- 22 Mesoporous ASD ? Fundamentals -- 23 Mesoporous Silica Drug Delivery Systems. 330 $aThis volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future. . 410 0$aAdvances in Delivery Science and Technology,$x2192-6204 606 $aPharmaceutical technology 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 615 0$aPharmaceutical technology. 615 14$aPharmaceutical Sciences/Technology. 676 $a615.7 702 $aShah$b Navnit$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSandhu$b Harpreet$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChoi$b Duk Soon$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChokshi$b Hitesh$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMalick$b A. Waseem$4edt$4http://id.loc.gov/vocabulary/relators/edt 712 02$aControlled Release Society, 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298352103321 996 $aAmorphous Solid Dispersions$92539487 997 $aUNINA