LEADER 04873nam 22008055 450 001 9910298351803321 005 20200703022544.0 010 $a1-4471-6311-7 024 7 $a10.1007/978-1-4471-6311-4 035 $a(CKB)3710000000089053 035 $a(EBL)1698286 035 $a(OCoLC)874179142 035 $a(SSID)ssj0001169924 035 $a(PQKBManifestationID)11748780 035 $a(PQKBTitleCode)TC0001169924 035 $a(PQKBWorkID)11166246 035 $a(PQKB)11606097 035 $a(MiAaPQ)EBC1698286 035 $a(DE-He213)978-1-4471-6311-4 035 $a(PPN)176750487 035 $a(EXLCZ)993710000000089053 100 $a20140218d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTrichloroethylene: Toxicity and Health Risks$b[electronic resource] /$fedited by Kathleen M. Gilbert, Sarah J. Blossom 205 $a1st ed. 2014. 210 1$aLondon :$cSpringer London :$cImprint: Springer,$d2014. 215 $a1 online resource (249 p.) 225 1 $aMolecular and Integrative Toxicology,$x2168-4219 300 $aDescription based upon print version of record. 311 $a1-4471-6310-9 320 $aIncludes bibliographical references and index. 327 $aHistory of TCE -- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis -- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models -- Role of Trichloroethylene in Parkinson?s disease -- Neuroimmune effects of developmental TCE exposure -- Environmental sensitivity to trichloroethylene (TCE) in the developing heart -- Trichloroethylene and Cancer -- Epigenetic Alterations Due to Trichloroethylene -- Mathematical Modeling and Trichloroethylene  . 330 $aA comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity. 410 0$aMolecular and Integrative Toxicology,$x2168-4219 606 $aPharmacology 606 $aEpidemiology 606 $aMolecular biology 606 $aImmunology 606 $aMedical biochemistry 606 $aEnvironmental health 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aEpidemiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H63000 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 606 $aEnvironmental Health$3https://scigraph.springernature.com/ontologies/product-market-codes/U18005 615 0$aPharmacology. 615 0$aEpidemiology. 615 0$aMolecular biology. 615 0$aImmunology. 615 0$aMedical biochemistry. 615 0$aEnvironmental health. 615 14$aPharmacology/Toxicology. 615 24$aEpidemiology. 615 24$aMolecular Medicine. 615 24$aImmunology. 615 24$aMedical Biochemistry. 615 24$aEnvironmental Health. 676 $a615.902 700 $aGilbert$b Kathleen M$01243450 702 $aGilbert$b Kathleen M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBlossom$b Sarah J$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298351803321 996 $aTrichloroethylene: Toxicity and Health Risks$92884161 997 $aUNINA