LEADER 04437nam 22007335 450 001 9910298351203321 005 20200704021746.0 010 $a94-017-9153-8 024 7 $a10.1007/978-94-017-9153-3 035 $a(CKB)3710000000187312 035 $a(EBL)1783798 035 $a(OCoLC)884961225 035 $a(SSID)ssj0001295357 035 $a(PQKBManifestationID)11857555 035 $a(PQKBTitleCode)TC0001295357 035 $a(PQKBWorkID)11343359 035 $a(PQKB)11254686 035 $a(MiAaPQ)EBC1783798 035 $a(DE-He213)978-94-017-9153-3 035 $a(PPN)179926608 035 $a(EXLCZ)993710000000187312 100 $a20140714d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aI Domain Integrins /$fedited by Donald Gullberg 205 $a1st ed. 2014. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2014. 215 $a1 online resource (188 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v819 300 $aDescription based upon print version of record. 311 $a1-322-47752-3 311 $a94-017-9152-X 320 $aIncludes bibliographical references and index. 327 $aPreface -- 1 Evolution of integrin I domains -- 2 Integrin a1b1 -- 3 Integrin a2b1 -- 4 Integrin a10b1- a collagen receptor critical in skeletal development -- 5 Integrin a11b1 ? a major collagen receptor on fibroblastic cells -- 6 Regulation of integrin activity by phosphorylation -- 7 Integrin aEb7:molecular features and functional significance in the immune system -- 8 Structural aspects of integrins -- 9 Integrin recognition motifs in the human collagens -- 10 Cellular signalling by collagen-binding integrins -- 11 The therapeutic potential of I-domain integrins -- Index. 330 $aThe integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v819 606 $aMedicine 606 $aLife sciences 606 $aMedical genetics 606 $aMedical biochemistry 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aLife Sciences, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L00004 606 $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 615 0$aMedicine. 615 0$aLife sciences. 615 0$aMedical genetics. 615 0$aMedical biochemistry. 615 14$aBiomedicine, general. 615 24$aLife Sciences, general. 615 24$aGene Function. 615 24$aMedical Biochemistry. 676 $a572.68 702 $aGullberg$b Donald$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298351203321 996 $aI Domain Integrins$92537307 997 $aUNINA