LEADER 05572nam 22006615 450 001 9910298350603321 005 20200704232005.0 010 $a1-4939-1227-5 024 7 $a10.1007/978-1-4939-1227-8 035 $a(CKB)3710000000225189 035 $a(EBL)1802650 035 $a(SSID)ssj0001338286 035 $a(PQKBManifestationID)11898417 035 $a(PQKBTitleCode)TC0001338286 035 $a(PQKBWorkID)11337607 035 $a(PQKB)10540672 035 $a(MiAaPQ)EBC1802650 035 $a(DE-He213)978-1-4939-1227-8 035 $a(PPN)180627929 035 $a(EXLCZ)993710000000225189 100 $a20140822d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCardiac Energy Metabolism in Health and Disease$b[electronic resource] /$fedited by Gary D. Lopaschuk, Naranjan S. Dhalla 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (301 p.) 225 1 $aAdvances in Biochemistry in Health and Disease ;$v11 300 $aDescription based upon print version of record. 311 $a1-322-13333-6 311 $a1-4939-1226-7 320 $aIncludes bibliographical references and index. 327 $aPart 1. Control of Energy Metabolism -- 1. A Primer on Carbohydrate Metabolism in the Heart -- 2. Lipoproteins: A Source of Cardiac Lipids -- 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart -- 4. Control of Myocardial Fatty Acid Uptake -- 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes -- 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation -- 7. Relationship between Substrate Metabolism and Cardiac Efficiency -- 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity -- Part 2. Alteration in Energy Metabolism -- 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes -- 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart -- 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure -- 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury -- 13. The Role of AMPK in the Control of Cardiac Hypertrophy -- 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance -- Part 3. Optimization of Energy Metabolism -- 15. Metabolic Therapy for the Ischemic Heart -- 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients -- 17. Cardiac Metabolic Protection for the Newborn Heart -- 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease. 330 $aThe heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.  The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change in this energy supply can seriously compromise cardiac function.  It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease.  It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional, and physiological levels.  It also describes how alterations in energy metabolism contribute to the development of heart dysfunction, and how optimization of energy metabolism can be used to treat heart disease.  The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics.  The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals. 410 0$aAdvances in Biochemistry in Health and Disease ;$v11 606 $aBiochemistry 606 $aMetabolism 606 $aCardiology 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aMetabolomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15030 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 615 0$aBiochemistry. 615 0$aMetabolism. 615 0$aCardiology. 615 14$aBiochemistry, general. 615 24$aMetabolomics. 615 24$aCardiology. 676 $a612.173 676 $a616.1205 702 $aLopaschuk$b Gary D$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDhalla$b Naranjan S$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298350603321 996 $aCardiac Energy Metabolism in Health and Disease$92537304 997 $aUNINA LEADER 05464nam 22007094a 450 001 9910171005403321 005 20240405040546.0 010 $a1-134-61134-X 010 $a0-203-17073-3 010 $a0-203-01475-8 010 $a1-280-33420-7 035 $a(CKB)1000000000251091 035 $a(EBL)178161 035 $a(OCoLC)49569356 035 $a(SSID)ssj0000182909 035 $a(PQKBManifestationID)11179779 035 $a(PQKBTitleCode)TC0000182909 035 $a(PQKBWorkID)10172050 035 $a(PQKB)10419855 035 $a(SSID)ssj0000300401 035 $a(PQKBManifestationID)12095766 035 $a(PQKBTitleCode)TC0000300401 035 $a(PQKBWorkID)10251279 035 $a(PQKB)10916509 035 $a(Au-PeEL)EBL178161 035 $a(CaPaEBR)ebr10017012 035 $a(CaONFJC)MIL33420 035 $a(MiAaPQ)EBC178161 035 $a(PPN)198450648 035 $a(EXLCZ)991000000000251091 100 $a19990326d1999 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIntroduction to social security$b[electronic resource] $epolicies, benefits, and poverty /$fedited by John Ditch 205 $a1st ed. 210 $aLondon ;$aNew York $cRoutledge$d1999 215 $a1 online resource (239 p.) 300 $aDescription based upon print version of record. 311 $a0-415-21431-9 311 $a0-415-21430-0 320 $aIncludes bibliographical references and index. 327 $aBook Cover; Half-Title; Title; Copyright; Dedication; Contents; Illustrations; Contributors; Preface; Abbreviations; Introduction; Conclusion; References; 1 The nature of poverty; Why is poverty important?; The definition of poverty; The measurement of poverty; Resources; Unit of analysis; Spatial issues; Equivalence; Time dimension; Income or expenditure?; Poverty lines and poverty gaps; Poverty in the UK; How does poverty in Britain compare?; Conclusion; Note; References; 2 The aims of social security; Introduction; Old and familiar aims; The relief of poverty?; Meeting needs 327 $aIncome maintenance and replacement Compensation; Redistribution; The new project for social security; Passive and active aims; Getting people into work; Changing behaviour; Conclusion; Notes; References; 3 Development of social security; What role for social security policy?; Critical questions; People; Principles; Policy; The legacy of Beveridge; People; Principles; Policy; The drift to selectivity; People; Principles; Policy; Privatisation and targeting; People; Principles; Policy; References; 4 Poverty and the adequacy of social security; Why does adequacy matter? 327 $aWhat is the income maintenance system?Values and ideologies; The context of adequacy; Adequacy for what?; Human needs; Perspectives on poverty measures; Adequacy for how long?; Time-scale; Adequacy for whom?; Precariousness; Compensation; Stratification; Ethnicity; Adequate according to whom?; Whose perspectives? Expertise; Package deal thinking; Government objectives; Is social security adequate in the UK?; Empirical surveys; Normative studies; Other approaches; Official UK approaches to adequacy questions; Conclusion; Notes; References; 5 British pensions policies; Introduction 327 $aThe importance of pensions Options and choices; Structure; Finance and private provision; The evolution of pensions in Britain; The post-war debate; The pensions White Paper chase; Pensions post-1979; Problems and responses in the 1990's; The case for change; Pensioners' incomes in the 1990's and future options; Conclusion-another fresh start; Acknowledgements; References; 6 Claiming entitlements; Introduction; The importance of take-up; Measuring take-up; Reasons for non-take-up; The Kerr model; The Ritchie and Matthews model; The econometric approach 327 $aVan Oorschot's interactive model of multi-level influences Dynamic aspects of take-up; Policy response and the way forward; References; 7 Social security, poverty and disability; Disability and the risk of poverty; The causes of poverty among disabled people; Employment and earnings; The additional costs of disability; The costs of personal assistance; Disability and social security; Income replacement benefits; Benefits for extra costs; Recent developments; Disability Living Allowance; Disability Working Allowance; ...Some You Lose? Restricting Invalidity Benefit 327 $aThe impact of disability on household incomes 330 $aSocial Security forms a major area of government policy and social expenditure. Government activity in this area impacts directly on all citizens, and consequently social security policy is the focus for much debate. People are affected by social security whether by funding it through taxation, or using it when claiming unemployment or other benefits. Introduction to Social Security is an up-to-date text on this important and complex social policy issue. It provides a second introduction for students of social policy and administration and includes contributions from some 606 $aSocial security$zGreat Britain 615 0$aSocial security 676 $a368.4/00941 701 $aDitch$b John$f1952-$0906151 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910171005403321 996 $aIntroduction to social security$92026719 997 $aUNINA