LEADER 04648nam 22006855 450 001 9910298350403321 005 20200630053558.0 010 $a1-4939-1154-6 024 7 $a10.1007/978-1-4939-1154-7 035 $a(CKB)3710000000225191 035 $a(EBL)1802625 035 $a(SSID)ssj0001338296 035 $a(PQKBManifestationID)11742988 035 $a(PQKBTitleCode)TC0001338296 035 $a(PQKBWorkID)11337961 035 $a(PQKB)10538152 035 $a(MiAaPQ)EBC1802625 035 $a(DE-He213)978-1-4939-1154-7 035 $a(PPN)180623788 035 $a(EXLCZ)993710000000225191 100 $a20140823d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGlycobiology of the Nervous System /$fedited by Robert K. Yu, Cara-Lynne Schengrund 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (590 p.) 225 1 $aAdvances in Neurobiology,$x2190-5215 ;$v9 300 $aDescription based upon print version of record. 311 $a1-322-13328-X 311 $a1-4939-1153-8 320 $aIncludes bibliographical references and index. 327 $aIntroduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates -- Introduction to Cells Comprising the Nervous System -- Synthesis, Processing, and Function of N-glycans in N-glycoproteins -- Synthesis of O-linked Glycoconjugates in the Nervous System -- Chemistry and Function of Glycosaminoglycans in the Nervous System -- Use of Glycan-targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous System -- From Mass Spectrometry-based Glycosylation Analysis to Glycomics and Glycoproteomic -- Structural Analysis of Oligosaccharides and Glycoconjugates using NMR -- Glycolipid and Glycoprotein Expression During Neural Development -- Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System -- Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System -- Role of Galactosylceramide and Sulfatide in Oligodendrocytes and CNS Myelin: Formation of a Glycosynapse -- Glycosignaling ? A General Review -- Glycosphingolipids in the Regulation of the Nervous System -- Glycobiology of Ion Transport in the Nervous System -- O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration -- N-glycosylation in Regulation of the Nervous System -- Roles of Carbohydrates in the Interaction of Pathogens with Neural Cells -- Glycoconjugate Changes in Aging and Age-related Diseases -- Gangliosides and Glycolipids in Neurodegenerative Disorders -- Glycosidases: Inborn Errors of Glycosphingolipid Catabolism -- Ganglioside Storage Diseases: On the Road to Management -- Dynamic Aspects of Neural Tumor Gangliosides -- Galectins and Neuroinflammation -- Glycoconjugates and Neuroimmunological Diseases. 330 $aA thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators. 410 0$aAdvances in Neurobiology,$x2190-5215 ;$v9 606 $aNeurosciences 606 $aNeurobiology 606 $aNeurochemistry 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 606 $aNeurochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/B18010 615 0$aNeurosciences. 615 0$aNeurobiology. 615 0$aNeurochemistry. 615 14$aNeurosciences. 615 24$aNeurobiology. 615 24$aNeurochemistry. 676 $a572.567 702 $aYu$b Robert K$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSchengrund$b Cara-Lynne$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298350403321 996 $aGlycobiology of the Nervous System$92975430 997 $aUNINA