LEADER 05178nam 22008055 450 001 9910298349303321 005 20200703210745.0 010 $a1-4899-8056-3 024 7 $a10.1007/978-1-4899-8056-4 035 $a(CKB)3710000000087958 035 $a(EBL)1698301 035 $a(OCoLC)880448075 035 $a(SSID)ssj0001185997 035 $a(PQKBManifestationID)11654415 035 $a(PQKBTitleCode)TC0001185997 035 $a(PQKBWorkID)11217417 035 $a(PQKB)11700207 035 $a(MiAaPQ)EBC1698301 035 $a(DE-He213)978-1-4899-8056-4 035 $a(PPN)176749837 035 $a(EXLCZ)993710000000087958 100 $a20140210d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTumor-Induced Immune Suppression$b[electronic resource] $eMechanisms and Therapeutic Reversal /$fedited by Dmitry I. Gabrilovich, Arthur Andrew Hurwitz 205 $a2nd ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (471 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-8055-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface.- Regulatory T Cells and Cancer -- Th17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 ? Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer -- Index. 330 $aTumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy  to provide breakthroughs in cancer treatment.  It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,  but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune  suppression to make any progress in the field and this monograph provides these important insights. 606 $aCancer research 606 $aImmunology 606 $aMedical microbiology 606 $aCell biology 606 $aHuman genetics 606 $aDevelopmental biology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aDevelopmental Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L18000 615 0$aCancer research. 615 0$aImmunology. 615 0$aMedical microbiology. 615 0$aCell biology. 615 0$aHuman genetics. 615 0$aDevelopmental biology. 615 14$aCancer Research. 615 24$aImmunology. 615 24$aMedical Microbiology. 615 24$aCell Biology. 615 24$aHuman Genetics. 615 24$aDevelopmental Biology. 676 $a571.6 676 $a571.8 676 $a599935 676 $a610 702 $aGabrilovich$b Dmitry I$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHurwitz$b Arthur Andrew$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298349303321 996 $aTumor-Induced Immune Suppression$92508872 997 $aUNINA