LEADER 01708oam 2200445I 450 001 9910701310103321 005 20141217163701.0 035 $a(CKB)5470000002417971 035 $a(OCoLC)658853779 035 $a(EXLCZ)995470000002417971 100 $a20100827d2010 ua 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEffects of the February 2010 snowstorms on airline performance /$fby Jenny Guarino and Theresa Firestine 210 1$a[Washington, D.C.] :$cU.S. Department of Transportation, Research and Innovative Technology Administration, Bureau of Transportation Statistics,$d2010. 215 $a1 online resource (8 pages) $ccolor illustrations, charts, map 225 1 $aSpecial report ;$vSR-021 300 $aTitle from PDF title page (viewed on August 27, 2010). 300 $a"August 2010." 320 $aIncludes bibliographical references. 606 $aRunways (Aeronautics)$xSnow and ice control$zUnited States 606 $aAirlines$xPerformance$zUnited States 615 0$aRunways (Aeronautics)$xSnow and ice control 615 0$aAirlines$xPerformance 700 $aGuarino$b Jenny$01409005 702 $aFirestine$b Theresa 712 02$aUnited States.$bDepartment of Transportation.$bResearch and Innovative Technology Administration. 712 02$aUnited States.$bBureau of Transportation Statistics, 801 0$bCBT 801 1$bCBT 801 2$bOCLCQ 801 2$bOCLCA 801 2$bGPO 906 $aBOOK 912 $a9910701310103321 996 $aEffects of the February 2010 snowstorms on airline performance$93543959 997 $aUNINA LEADER 04582oam 2200493 450 001 9910298347803321 005 20190911103512.0 010 $a1-4614-9317-X 024 7 $a10.1007/978-1-4614-9317-4 035 $a(OCoLC)870515452 035 $a(MiFhGG)GVRL6YWC 035 $a(EXLCZ)993710000000083338 100 $a20131127d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aDiabetic cardiomyopathy $ebiochemical and molecular mechanisms /$fBelma Turan, Naranjan S. Dhalla, editors 205 $a1st ed. 2014. 210 1$aNew York :$cSpringer,$d2014. 215 $a1 online resource (xix, 416 pages) $cillustrations (some color) 225 1 $aAdvances in Biochemistry in Health and Disease ;$v9 300 $aDescription based upon print version of record. 311 $a1-4614-9316-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCardiac defects in diabetes -- Hormonal imbalance and neuropathy -- Role of oxidative stress -- Role of cation channel defects -- Abnormalities in glucose transport -- Fatty acid utilization -- Sarcolemmal Na+-K+ ATPase -- Sarcolemmal Ca2+-transport -- Sarcoplasmic reticular Ca2+-transport -- Intracellular Ca2+-homeostasis -- Mitochondrial function -- Contractile proteins -- ?-adrenoceptor mechanisms -- Protein kinases and signal transduction -- Regulation of phopholipases -- Endothelin defects and cardiac dysfunction -- Metabolic changes in smooth muscles -- Metabolic defects in skeletal muscles -- Metabolic defects in brain -- Role of microangiopathy in heart dysfunction -- Role of nephropathy in heart dysfunction -- Prevention of diabetic-induced cardiac dysfunction -- Molecular targets for the therapy of diabetic cardiomyopathy. 330 $aDiabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease.  Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction. 410 0$aAdvances in biochemistry in health and disease ;$vv. 9. 606 $aMyocardium$xDiseases$xPathophysiology 606 $aDiabetes$xComplications 606 $aClinical biochemistry 615 0$aMyocardium$xDiseases$xPathophysiology. 615 0$aDiabetes$xComplications. 615 0$aClinical biochemistry. 676 $a616.1071 702 $aTuran$b Belma 702 $aDhalla$b Naranjan S. 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910298347803321 996 $aDiabetic Cardiomyopathy$92503032 997 $aUNINA