LEADER 04233nam 22006735 450 001 9910298346303321 005 20200701080910.0 010 $a3-319-08162-4 024 7 $a10.1007/978-3-319-08162-5 035 $a(CKB)3710000000261984 035 $a(EBL)1967221 035 $a(OCoLC)896834353 035 $a(SSID)ssj0001372161 035 $a(PQKBManifestationID)11753108 035 $a(PQKBTitleCode)TC0001372161 035 $a(PQKBWorkID)11301529 035 $a(PQKB)10959862 035 $a(MiAaPQ)EBC1967221 035 $a(DE-He213)978-3-319-08162-5 035 $a(PPN)182096580 035 $a(EXLCZ)993710000000261984 100 $a20141013d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$amiRNAs and Target Genes in Breast Cancer Metastasis /$fby Seema Sethi 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (83 p.) 225 1 $aSpringerBriefs in Cancer Research,$x2194-1173 300 $aDescription based upon print version of record. 311 $a3-319-08161-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aRole of miRNAs and their Target Genes in Breast Cancer Metastasis -- Molecular Pathogenesis of Breast Cancer and the Role of MicroRNAs -- Epidemiology, Risk Factors, Treatment and Prevention of Breast Cancer Metastases -- Clinical Perspectives: Breast Cancer Brain Metastasis -- Molecular targeted therapy for brain metastatic breast cancers: Current Updates. 330 $aThis SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy.   The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically modified anti-miRNA oligonucleotides), which could prevent the development of metastasis; whereas once metastasis develops then it could be treated with miRNA mimics for inducing its expression for the treatment. Therefore, development of miRNA-based prophylactic therapies could serve as precision and personalized medicine against future development of metastasis of breast and other cancers. 410 0$aSpringerBriefs in Cancer Research,$x2194-1173 606 $aCancer research 606 $aGene expression 606 $aOncology   606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aCancer research. 615 0$aGene expression. 615 0$aOncology  . 615 14$aCancer Research. 615 24$aGene Expression. 615 24$aOncology. 676 $a610 676 $a611.01816 676 $a614.5999 676 $a616994 700 $aSethi$b Seema$4aut$4http://id.loc.gov/vocabulary/relators/aut$01064622 906 $aBOOK 912 $a9910298346303321 996 $aMiRNAs and Target Genes in Breast Cancer Metastasis$92539481 997 $aUNINA