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200 10$aNeurobiological Studies of Addiction in Chronic Pain States$b[electronic resource] /$fedited by Carolyn A. Fairbanks, Thomas J. Martin, Ph.D
205   $a1st ed. 2014.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014.
215   $a1 online resource (137 p.)
225 1 $aContemporary Clinical Neuroscience,$x2627-535X ;$v17
300   $aDescription based upon print version of record.
311   $a1-4939-1855-9 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aOpioid and Non-Opioid Drug Responding Under States of Chronic Pain: A Timeline Spanning 1980 to Present Day -- Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or Addiction -- The Influence of Pain on Reward Processing: Current Literature and Prospects -- Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward -- Drug Addiction and Chronic Pain: A Review of Animal Models -- Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary -- Prenatal Exposure to Opioids -- Opioids in an Evidence-Based World.
330   $aUsing rodent models, the contributors explore the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction. Combining various pain models with opioid self-administration and central administration pharmacotherapies allows researchers to answer important questions about: 1. The efficacy of opioid treatment under conditions of chronic pain of different etiology. 2. Alterations in the efficacy of opioid treatment under conditions of long-term opioid pharmacotherapy. 3. The potential for conversion or escalation of extra-analgesic motivation for opioid use beyond that required for pain relief. 4. The possibility of addiction development in chronic pain sufferers. Merging the field of pain researchers with that of addiction research has presented some unique challenges and this volume seeks to provide some guidance for future study design in addition to a summary of current findings in the area.
410  0$aContemporary Clinical Neuroscience,$x2627-535X ;$v17
606   $aNeurosciences
606   $aPain medicine
606   $aAnimal models in research
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aPain Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H47003
606   $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050
615  0$aNeurosciences.
615  0$aPain medicine.
615  0$aAnimal models in research.
615 14$aNeurosciences.
615 24$aPain Medicine.
615 24$aAnimal Models.
676   $a610
676   $a612.8
676   $a616.027
676   $a616.0472
702   $aFairbanks$b Carolyn A$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMartin$b Ph.D., Thomas J$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298345403321
996   $aNeurobiological Studies of Addiction in Chronic Pain States$92498401
997   $aUNINA