LEADER 04014nam 22005895 450 001 9910298344003321 005 20200706052829.0 010 $a3-319-07395-8 024 7 $a10.1007/978-3-319-07395-8 035 $a(CKB)3710000000228690 035 $a(EBL)1966781 035 $a(OCoLC)890911178 035 $a(SSID)ssj0001353673 035 $a(PQKBManifestationID)11868557 035 $a(PQKBTitleCode)TC0001353673 035 $a(PQKBWorkID)11316132 035 $a(PQKB)10110557 035 $a(MiAaPQ)EBC1966781 035 $a(DE-He213)978-3-319-07395-8 035 $a(PPN)181352826 035 $a(EXLCZ)993710000000228690 100 $a20140902d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTranscriptional Control of Lineage Differentiation in Immune Cells /$fedited by Wilfried Ellmeier, Ichiro Taniuchi 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (334 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v381 300 $aDescription based upon print version of record. 311 $a3-319-07394-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aGenetic and epigenetic control of early lymphocyte development -- The role of BTB-zinc finger transcription factors during T cell development and in the regulation of T cell-mediated immunity -- Transcriptional control of the development and function of V?14i NKT cells -- Transcriptional Control of Regulatory T cells -- Transcriptional regulatory networks for CD4 T cell differentiation -- Transcriptional control of NK cell differentiation and function -- Transcriptional control of pre-B cell development and leukemia prevention -- Transcription factors controlling innate lymphoid cell fate decisions -- Transcriptional control of dendritic cell differentiation -- Helper T cell plasticity: Impact of Extrinsic and Intrinsic Signals On Transcriptomes and Epigenomes. 330 $aInsights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade. 410 0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v381 606 $aImmunology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aImmunology. 615 14$aImmunology. 676 $a612 702 $aEllmeier$b Wilfried$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTaniuchi$b Ichiro$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298344003321 996 $aTranscriptional Control of Lineage Differentiation in Immune Cells$92513131 997 $aUNINA