LEADER 04568nam 22006735 450 001 9910298341003321 005 20200701035610.0 010 $a1-4939-1426-X 024 7 $a10.1007/978-1-4939-1426-5 035 $a(CKB)3710000000248638 035 $a(EBL)1968176 035 $a(OCoLC)908088918 035 $a(SSID)ssj0001353628 035 $a(PQKBManifestationID)11867739 035 $a(PQKBTitleCode)TC0001353628 035 $a(PQKBWorkID)11317417 035 $a(PQKB)11183830 035 $a(MiAaPQ)EBC1968176 035 $a(DE-He213)978-1-4939-1426-5 035 $z(PPN)258857668 035 $a(PPN)181354098 035 $a(EXLCZ)993710000000248638 100 $a20140922d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aExtrasynaptic GABAA Receptors /$fedited by Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (301 p.) 225 1 $aThe Receptors,$x1048-6909 ;$v27 300 $aDescription based upon print version of record. 311 $a1-4939-1425-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aA brief introduction to extrasynaptic GABAA receptors and ?tonic? GABAA receptor mediated inhibition in physiology and disease -- Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation -- Biophysical properties of recombinant 2- AND ?- subunit containing GABAA receptors -- The pharmacology of extrasynaptic GABAA receptors -- Neurosteroids and extrasynaptic GABAA receptors -- Sources of GABA that activate extrasynaptic GABAA receptors -- Modulation of Extrasynaptic GABAA Receptors by G-protein-coupled Receptors -- Extrasynaptic GABAA receptors and tonic inhibition in spinal cord -- The role of peri-synaptic GABA receptors after stroke -- The role of extrasynaptic GABAA receptors in focal epilepsy -- Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures -- GABAergic control of the hypothalamic-pituitary-adrenal (HPA) axis: role of extrasynaptic GABAA receptors -- Tonic GABAA receptor mediated inhibition in Fragile-X Syndrome: A cause of dysfunction or a pathway for a cure? 330 $aGABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed ?tonic? inhibition, has been described. Whereas synaptic GABAA receptors underlie classical ?phasic? GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes. 410 0$aThe Receptors,$x1048-6909 ;$v27 606 $aNeurosciences 606 $aPharmacology 606 $aNeurology  606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 615 0$aNeurosciences. 615 0$aPharmacology. 615 0$aNeurology . 615 14$aNeurosciences. 615 24$aPharmacology/Toxicology. 615 24$aNeurology. 676 $a616.8 702 $aErrington$b Adam C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDi Giovanni$b Giuseppe$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCrunelli$b Vincenzo$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298341003321 996 $aExtrasynaptic GABAA Receptors$92544098 997 $aUNINA