LEADER 04124nam 22006615 450 001 9910298340803321 005 20200704035249.0 010 $a1-4939-1429-4 024 7 $a10.1007/978-1-4939-1429-6 035 $a(CKB)3710000000248639 035 $a(EBL)1965072 035 $a(OCoLC)893678503 035 $a(SSID)ssj0001353647 035 $a(PQKBManifestationID)11867740 035 $a(PQKBTitleCode)TC0001353647 035 $a(PQKBWorkID)11317418 035 $a(PQKB)10974157 035 $a(MiAaPQ)EBC1965072 035 $a(DE-He213)978-1-4939-1429-6 035 $a(PPN)181348039 035 $a(EXLCZ)993710000000248639 100 $a20140922d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMicroglia in Health and Disease /$fedited by Marie-Ève Tremblay, Amanda Sierra 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (490 p.) 300 $aDescription based upon print version of record. 311 $a1-4939-1428-6 320 $aIncludes bibliographical references and index at the end of each chapters. 327 $aIntroduction -- Historical Context -- Microglial Physiology -- Lessons from in vivo Imaging -- Roles in Immune Responses -- Neuroprotection Versus Neurotoxicity -- Developmental Neuronal Elimination -- Developmental Angiogenesis, Myelination and Astrogliogenesis -- Developing and Mature Synapses -- Adult Neurogenesis, Learning and Memory -- Neuropathic Pain -- Drug Addiction -- Aging -- Neurodevelopmental and Neuropsychiatric Disorders -- Human Immunodeficiency Virus -- Multiple Sclerosis -- Ischemia and Stroke -- Neurodegenerative Diseases -- Spinal Cord and Brain Trauma. 330 $aThese past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly what they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury. 606 $aNeurosciences 606 $aNeurobiology 606 $aImmunology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aNeurosciences. 615 0$aNeurobiology. 615 0$aImmunology. 615 14$aNeurosciences. 615 24$aNeurobiology. 615 24$aImmunology. 676 $a573.8 676 $a610 676 $a612.8 676 $a616079 702 $aTremblay$b Marie-Ève$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSierra$b Amanda$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298340803321 996 $aMicroglia in Health and Disease$92544097 997 $aUNINA