LEADER 05848nam 22007935 450 001 9910298340503321 005 20200702194644.0 010 $a94-017-9078-7 024 7 $a10.1007/978-94-017-9078-9 035 $a(CKB)3710000000262433 035 $a(EBL)1966694 035 $a(OCoLC)896834210 035 $a(SSID)ssj0001372189 035 $a(PQKBManifestationID)11802157 035 $a(PQKBTitleCode)TC0001372189 035 $a(PQKBWorkID)11304236 035 $a(PQKB)10652916 035 $a(MiAaPQ)EBC1966694 035 $a(DE-He213)978-94-017-9078-9 035 $a(PPN)182092429 035 $a(EXLCZ)993710000000262433 100 $a20141013d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTranslation and Its Regulation in Cancer Biology and Medicine$b[electronic resource] /$fedited by Armen Parsyan 205 $a1st ed. 2014. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2014. 215 $a1 online resource (709 p.) 300 $aDescription based upon print version of record. 311 $a94-017-9077-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface -- Introduction -- PART I. TRANSALATION MACHINERY IN CANCER -- Mechanism of Translation in Eukaryotes -- Diverse Mechanisms of Translation Regulation and Their Role in Cancer -- eIF4E and Its Binding Proteins -- RNA Helicases and Their Cofactors -- PDCD4 -- eIF4G -- eIF3 -- The eIF2 Complex and eIF2? -- eIF5A -- eIF6 -- Translation Elongation -- Ribosomes -- Current and Emerging Therapies Targeting Translation -- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER -- mTOR and Regulation of Translation -- Ribosomal Protein S6 and S6 Kinases -- eIF4E Phosphorylation Downstream of MAPK Pathway -- PART III. CELL FATE AND TRANSLATION IN CANCER -- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells -- Translation and Apoptosis in Cancer -- Translation in Cancer at Hypoxia -- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES -- Melanoma and Non-Melanoma Skin Cancers -- Sarcomas -- Hematological Malignancies and Premalignant Conditions -- Brain Tumors -- Head and Neck Cancers -- Breast Cancer -- Cancers of the Respiratory System -- Gastric and Esophageal Cancers -- Colorectal Cancers -- Hepatic, Pancreatic and Biliary Cancers -- Pancreatic Neuroendocrine Tumors -- Gynecologic Cancers -- Prostate Cancer -- Cancers of the Urinary System -- List of Abbreviations. 330 $aThis book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.  The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.   The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.    . 606 $aCancer research 606 $aOncology   606 $aCell biology 606 $aMolecular biology 606 $aBiochemistry 606 $aMedicine 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aCancer research. 615 0$aOncology  . 615 0$aCell biology. 615 0$aMolecular biology. 615 0$aBiochemistry. 615 0$aMedicine. 615 14$aCancer Research. 615 24$aOncology. 615 24$aCell Biology. 615 24$aMolecular Medicine. 615 24$aBiochemistry, general. 615 24$aBiomedicine, general. 676 $a571.6 676 $a572 676 $a610 676 $a611.01816 702 $aParsyan$b Armen$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298340503321 996 $aTranslation and Its Regulation in Cancer Biology and Medicine$92544741 997 $aUNINA