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010   $a3-7091-1431-4
024 7 $a10.1007/978-3-7091-1431-5
035   $a(CKB)3710000000281329
035   $a(EBL)1966147
035   $a(OCoLC)895661324
035   $a(SSID)ssj0001385832
035   $a(PQKBManifestationID)11779491
035   $a(PQKBTitleCode)TC0001385832
035   $a(PQKBWorkID)11349635
035   $a(PQKB)10659211
035   $a(MiAaPQ)EBC1966147
035   $a(DE-He213)978-3-7091-1431-5
035   $a(PPN)183085361
035   $a(EXLCZ)993710000000281329
100   $a20141114d2014      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGlioma Cell Biology /$fedited by Aleksi Sedo, Rolf Mentlein
205   $a1st ed. 2014.
210  1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2014.
215   $a1 online resource (466 p.)
300   $aDescription based upon print version of record.
311   $a3-7091-1430-6 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aThe inner space: Molecular mechanisms driving the malignant phenotype of glioma cells: Cancer stem cells and glioblastoma -- Epigenetic changes in gliomas -- Signaling cascades and transcription factors driving the malignant phenotype of glioma cells -- MicroRNAs in molecular pathology of gliomas -- Autophagy in glioma cells.-   Partnership: Glioma cell partners and the tumor microenvironment: Auto- and paracrine mediators in the glioma microenvironment -- Angiogenesis in gliomas -- Immune response ? gliomas-associated immunosuppression -- Microglia in gliomas: friend or foe? Glioma and Extracellular Matrix -- Glioblastomas and the special role of adhesion molecules in their invasion -- Glioma-associated proteases -- Interactions: Concepts and tools in glioma research:- Experimental models of glioma -- Models to study glioma cell invasion.          .
330   $aGliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions),  tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology.
606   $aNeurosciences
606   $aOncology
606   $aMolecular biology
606   $aCancer$xResearch
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aNeurosciences.
615  0$aOncology.
615  0$aMolecular biology.
615  0$aCancer$xResearch.
615 14$aNeurosciences.
615 24$aOncology.
615 24$aMolecular Medicine.
615 24$aCancer Research.
676   $a610
676   $a611.01816
676   $a612.8
676   $a614.5999
702   $aSedo$b Aleksi$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMentlein$b Rolf$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298337903321
996   $aGlioma Cell Biology$92537255
997   $aUNINA