LEADER 06437nam 22008415 450 001 9910298337603321 005 20230810162149.0 010 $a1-4939-0464-7 024 7 $a10.1007/978-1-4939-0464-8 035 $a(CKB)3710000000093411 035 $a(EBL)1698305 035 $a(OCoLC)880551523 035 $a(SSID)ssj0001185961 035 $a(PQKBManifestationID)11707363 035 $a(PQKBTitleCode)TC0001185961 035 $a(PQKBWorkID)11211944 035 $a(PQKB)10980552 035 $a(MiAaPQ)EBC1698305 035 $a(DE-He213)978-1-4939-0464-8 035 $a(PPN)177825847 035 $a(EXLCZ)993710000000093411 100 $a20140313d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPhospholipases in Health and Disease /$fedited by Paramjit S. Tappia, Naranjan S. Dhalla 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (416 p.) 225 1 $aAdvances in Biochemistry in Health and Disease,$x2512-2150 ;$v10 300 $aDescription based upon print version of record. 311 $a1-4939-0463-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPhospholipases in Health and Disease -- Role of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodelling in the Heart and Mammalian Cells -- Role of Phospholipases and Oxidized Phospholipids in Inflammation -- Phospholipases in Cardiovascular Disease -- The Structures and Functions of Intracellular Phospholipase A1 Family Proteins -- Phospholipase A and Breast Cancer -- Pathophysiological Aspects of Lipoprotein Associated Phospholipase A2: A Brief Overview -- Phospholipase A2 Activity Exhibited by a Bacterial Virulence Protein that Enters and Operates within a Variety of Host Cells -- Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease -- Cytoplasmic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers -- Phospholipase A2 Enzymes: Potential Targets for Therapy -- The Role of Phospholipase C Isozymes in Cellular Homeostasis -- Phospholipase C in the Immune Cell -- Phosphoinositide-specific Phospholipase C Enzymes and Cognitive Development  and Decline -- Where life begins: Sperm PLCz in mammalian egg activation and implications in male infertility -- Oocyte Activation and Phospholipase C zeta (PLC?): Male Infertility and  Implications for Therapeutic Intervention -- Phospholipase C Signaling in Heart Disease -- Activation of Phospholipase C in Cardiac Hypertrophy -- The Protective Effect of Phospholipase C From Cardiac Ischemia-Reperfusion Injury -- Role of Phospholipase C in Cardioprotection During Oxidative Stress -- Mammalian Phospholipase D: Structure, Regulation and Physiological Functions of Phospholipase D and its Link to Pathology -- Emerging Roles of Phospholipase D in Pathophysiological Signaling -- Alterations in Phospholipase D During the Development of Myocardial Disease. 330 $aPhospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development. 410 0$aAdvances in Biochemistry in Health and Disease,$x2512-2150 ;$v10 606 $aLipids 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aEnzymology 606 $aProteins 606 $aNeurosciences 606 $aBiological transport 606 $aCell membranes 606 $aLipidology 606 $aBiomedical Research 606 $aEnzymology 606 $aProteins 606 $aNeuroscience 606 $aMembrane Trafficking 615 0$aLipids. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aEnzymology. 615 0$aProteins. 615 0$aNeurosciences. 615 0$aBiological transport. 615 0$aCell membranes. 615 14$aLipidology. 615 24$aBiomedical Research. 615 24$aEnzymology. 615 24$aProteins. 615 24$aNeuroscience. 615 24$aMembrane Trafficking. 676 $a571.64 702 $aTappia$b Paramjit S$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDhalla$b Naranjan S$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298337603321 996 $aPhospholipases in Health and Disease$92513125 997 $aUNINA