LEADER 04564nam 22007095 450 001 9910298337003321 005 20230810183745.0 010 $a3-319-07911-5 024 7 $a10.1007/978-3-319-07911-0 035 $a(CKB)3710000000219374 035 $a(EBL)1802848 035 $a(SSID)ssj0001338288 035 $a(PQKBManifestationID)11743255 035 $a(PQKBTitleCode)TC0001338288 035 $a(PQKBWorkID)11338158 035 $a(PQKB)11448400 035 $a(MiAaPQ)EBC1802848 035 $a(DE-He213)978-3-319-07911-0 035 $a(PPN)180626973 035 $a(EXLCZ)993710000000219374 100 $a20140812d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFc Receptors /$fedited by Marc Daeron, Falk Nimmerjahn 205 $a1st ed. 2014. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2014. 215 $a1 online resource (426 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v382 300 $aDescription based upon print version of record. 311 $a1-322-13706-4 311 $a3-319-07910-7 320 $aIncludes bibliographical references and index. 327 $aThe Old but New IgM Fc Receptor (Fc?R) -- Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease -- Intracellular antibody immunity and the cytosolic Fc receptor TRIM21 -- Computational modeling of the main signaling pathways involved in mast cell activation -- Calcium channels in FcR signaling -- Regulation of Fc?RI signaling by lipid phosphatases -- Fc Receptors as Adaptive Immunoreceptors -- Glycosylation and Fc Receptors -- Antibodies as natural adjuvants -- IgA, IgA receptors and their anti-inflammatory properties -- Humanized mice to study Fc?R function -- FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions -- Human FcR polymorphism and disease -- Bridging auto-antibodies and arthritis; the role of Fc Receptors -- The Fc?R of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies -- FcgRIIB as a key determinant of agonistic antibody efficacy -- Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work -- Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G. 330 $aThis volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc?RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including Fc?RIIB and Fc?RI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v382 606 $aImmunology 606 $aProteins 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aImmunology 606 $aProteins 606 $aBiomedical Research 615 0$aImmunology. 615 0$aProteins. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aImmunology. 615 24$aProteins. 615 24$aBiomedical Research. 676 $a574.87 702 $aDaeron$b Marc$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNimmerjahn$b Falk$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298337003321 996 $aFc Receptors$92537254 997 $aUNINA