LEADER 04327nam 22006495 450 001 9910298335203321 005 20200629215958.0 010 $a1-4939-1683-1 024 7 $a10.1007/978-1-4939-1683-2 035 $a(CKB)3710000000261813 035 $a(EBL)1965022 035 $a(OCoLC)894508684 035 $a(SSID)ssj0001372163 035 $a(PQKBManifestationID)11831404 035 $a(PQKBTitleCode)TC0001372163 035 $a(PQKBWorkID)11301847 035 $a(PQKB)11517881 035 $a(MiAaPQ)EBC1965022 035 $a(DE-He213)978-1-4939-1683-2 035 $a(PPN)182093883 035 $a(EXLCZ)993710000000261813 100 $a20141020d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular Genetics of Dysregulated pH Homeostasis$b[electronic resource] /$fedited by Jen-Tsan Ashley Chi 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (158 p.) 300 $aDescription based upon print version of record. 311 $a1-4939-1682-3 320 $aIncludes bibliographical references at the end of eah chapters and index. 327 $aMolecular Genetics of Acid Sensing and Response -- Part I: Sensing Acidity -- The molecular mechanism of cellular sensing of acidity -- The Molecular Basis of Sour Sensing in Mammals -- Function and Signaling of the pH-sensing G protein-coupled receptors in physiology and diseases -- Part II: Response to Acidity -- The MondoA-TXNIP checkpoint couples the acidic tumor microenvironment to cell metabolism -- Regulation of Renal Glutamine Metabolisms during Metabolic Acidosis -- Extracellular acidosis and cancer -- The genomic analysis of cellular responses and adaptions to extracellular acidosis -- Index. 330 $aMost biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological function at every level, including protein folding, enzymatic activities and proliferation, and cell death. Therefore, maintaining the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in scientific literature and in medical textbooks.  However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events, and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases including cancer, stroke, myocardial infarction, diabetes, and renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and respond to acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanisms and cellular responses to pH alterations in both physiological (taste, pain) and pathological (ischemia and cancers) settings. Furthermore, the authors present a broad spectrum of investigative approaches to cellular response to acidosis in a wide variety of human diseases. 606 $aHuman genetics 606 $aCell biology 606 $aMedicine 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aHuman genetics. 615 0$aCell biology. 615 0$aMedicine. 615 14$aHuman Genetics. 615 24$aCell Biology. 615 24$aBiomedicine, general. 676 $a571.6 676 $a599935 676 $a610 676 $a611.01816 702 $aChi$b Jen-Tsan Ashley$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298335203321 996 $aMolecular Genetics of Dysregulated pH Homeostasis$92513121 997 $aUNINA