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010   $a1-4614-9167-3
024 7 $a10.1007/978-1-4614-9167-5
035   $a(CKB)3710000000073407
035   $a(EBL)1592113
035   $a(OCoLC)865580717
035   $a(SSID)ssj0001066444
035   $a(PQKBManifestationID)11579991
035   $a(PQKBTitleCode)TC0001066444
035   $a(PQKBWorkID)11066567
035   $a(PQKB)11423531
035   $a(MiAaPQ)EBC1592113
035   $a(DE-He213)978-1-4614-9167-5
035   $a(PPN)176100717
035   $a(EXLCZ)993710000000073407
100   $a20131108d2014      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aHypoxia and Cancer$b[electronic resource] $eBiological Implications and Therapeutic Opportunities /$fedited by Giovanni Melillo
205   $a1st ed. 2014.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Humana,$d2014.
215   $a1 online resource (362 p.)
225 1 $aCancer Drug Discovery and Development,$x2196-9906
300   $aDescription based upon print version of record.
311   $a1-4614-9166-5 
320   $aIncludes bibliographical references and index.
327   $aPreface -- Hypoxia and breast cancer metastasis -- Hypoxia and the DNA damage response -- Hypoxia and non-coding RNAs -- Hypoxia and ROS -- Hypoxia and gene expression -- Carbonic anhydrase IX: from biology to therapy -- Imaging the hypoxic tumor microenvironment in preclinical models -- Clinical imaging of hypoxia -- Hypoxia, antiangiogenic therapy and metastasis -- UPR and therapeutic opportunities -- Targeting the hypoxic phenotype -- Marianne Nordsmark: Hypoxia and Radiation therapy -- Pharmacological strategies targeting hypoxia -- Targeting the hypoxic tumor microenvironment -- Clinical exploitation of hypoxia -- Index.
330   $aThe tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for  understanding how hypoxia impacts the biology, imaging and therapy of human cancers.  Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy.
410  0$aCancer Drug Discovery and Development,$x2196-9906
606   $aCancer research
606   $aMolecular biology
606   $aPharmacology
606   $aStem cells
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010
615  0$aCancer research.
615  0$aMolecular biology.
615  0$aPharmacology.
615  0$aStem cells.
615 14$aCancer Research.
615 24$aMolecular Medicine.
615 24$aPharmacology/Toxicology.
615 24$aStem Cells.
676   $a614.5999
702   $aMelillo$b Giovanni$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298334303321
996   $aHypoxia and Cancer$92536206
997   $aUNINA